SEC61G

SEC61G
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WWB, 3J7R, 4CG7, 3J7Q, 4CG5, 4CG6
Identifiers
Aliases	SEC61G, SSS1, Sec61 translocon gamma subunit, SEC61 translocon subunit gamma
External IDs	OMIM: 609215; MGI: 1202066; HomoloGene: 40767; GeneCards: SEC61G; OMA:SEC61G - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	54,759,974 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	16,508,484 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; body of pancreas; ; anterior pituitary; ; islet of Langerhans; ; mucosa of transverse colon; ; corpus epididymis; ; ganglionic eminence; ; cartilage tissue; ; tendon of biceps brachii; ; ventricular zone;
	Top expressed in
	epiblast; ; primary oocyte; ; ileum; ; quadriceps femoris muscle; ; embryo; ; jejunum; ; bone marrow; ; embryo; ; neural tube; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-transporting ATPase activity; protein binding; protein transmembrane transporter activity;
Cellular component	integral component of membrane; cytosol; endoplasmic reticulum membrane; membrane; endoplasmic reticulum;
Biological process	protein targeting; protein transmembrane transport; protein targeting to ER; protein transport; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	23480
	20335
	ENSG00000132432
	ENSMUSG00000078974
	P60059
	P60060
	NM_014302; NM_001012456
	NM_001109971; NM_001109972; NM_011343
	NP_001012474; NP_055117
	NP_001103441; NP_001103442; NP_035473
	Wikidata
View/Edit Human	View/Edit Mouse

Protein transport protein Sec61 subunit gamma is a protein that in humans is encoded by the SEC61G gene.⁵⁶⁷

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified.⁷

References

GRCh38: Ensembl release 89: ENSG00000132432 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000078974 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
Greenfield JJ, High S (May 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". Journal of Cell Science. 112 ( Pt 10) (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
"Entrez Gene: SEC61G Sec61 gamma subunit".

Further reading

Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL (December 1996). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. Bibcode:1996Natur.384..432W. doi:10.1038/384432a0. PMID 8945469. S2CID 6276718.
Chen Y, Le Cahérec F, Chuck SL (May 1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". The Journal of Biological Chemistry. 273 (19): 11887–94. doi:10.1074/jbc.273.19.11887. PMID 9565615.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132432 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000078974 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8107851-5] Hartmann E, Sommer T, Prehn S, Görlich D, Jentsch S, Rapoport TA (February 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.

[pmid10212142-6] Greenfield JJ, High S (May 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". Journal of Cell Science. 112 ( Pt 10) (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.

[entrez-7] "Entrez Gene: SEC61G Sec61 gamma subunit".

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