SEC14L1

SEC14L1
Identifiers
Aliases	SEC14L1, PRELID4A, SEC14L, SEC14 like lipid binding 1
External IDs	OMIM: 601504; MGI: 1921386; HomoloGene: 37719; GeneCards: SEC14L1; OMA:SEC14L1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	77,217,101 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	117,050,094 bp
RNA expression pattern
	Top expressed in
	dorsal motor nucleus of vagus nerve; ; internal globus pallidus; ; blood; ; inferior olivary nucleus; ; lower lobe of lung; ; right lung; ; pericardium; ; olfactory bulb; ; sperm; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	submandibular gland; ; superior frontal gyrus; ; neural layer of retina; ; primary visual cortex; ; perirhinal cortex; ; lens; ; granulocyte; ; dorsal striatum; ; molar; ; CA3 field;
	More reference expression data
	n/a
Gene ontology
Molecular function	RIG-I binding; protein binding; molecular function regulator;
Cellular component	cytoplasm; Golgi apparatus; nucleoplasm; cytosol;
Biological process	negative regulation of signal transduction; innate immune response; negative regulation of RIG-I signaling pathway; choline transport; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	6397
	74136
	ENSG00000129657
	ENSMUSG00000020823
	Q92503
	A8Y5H7
NM_003003; NM_001039573; NM_001143998; NM_001143999; NM_001144001;
	NM_001204408; NM_001204410
	NM_001166506; NM_001166507; NM_028777; NM_001363165
NP_001034662; NP_001137470; NP_001137471; NP_001137473; NP_001191337;
	NP_001191339; NP_002994
	NP_001159978; NP_001159979; NP_083053; NP_001350094
	Wikidata
View/Edit Human	View/Edit Mouse

SEC14-like protein 1 is a protein that in humans is encoded by the SEC14L1 gene.⁵⁶

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system.⁶

References

GRCh38: Ensembl release 89: ENSG00000129657 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020823 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chinen K, Takahashi E, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region". Cytogenet Cell Genet. 73 (3): 218–23. doi:10.1159/000134342. PMID 8697811.
"Entrez Gene: SEC14L1 SEC14-like 1 (S. cerevisiae)".

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Kalikin LM, Bugeaud EM, Palmbos PL, et al. (2002). "Genomic characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag" (PDF). Mamm. Genome. 12 (12): 925–9. doi:10.1007/s00335-001-2073-3. hdl:2027.42/42124. PMID 11707779. S2CID 1547107.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129657 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020823 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8697811-5] Chinen K, Takahashi E, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region". Cytogenet Cell Genet. 73 (3): 218–23. doi:10.1159/000134342. PMID 8697811.

[entrez-6] "Entrez Gene: SEC14L1 SEC14-like 1 (S. cerevisiae)".

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