Article · Wikipedia archive · Last revised Jun 23, 2026

Sec-butomidate

Sec-butomidate is an anesthetic drug related to etomidate, which has been sold as a designer drug as an active ingredient in e-cigarette liquids marketed under names such as space oil or kpods. It has a sec-butyl ester group in place of the ethyl ester of etomidate.

Last revised
Jun 23, 2026
Read time
≈ 1 min
Length
190 w
Citations
4
Source
Wikipedia ↗
Sec-butomidate
Identifiers
  • but-2-yl 3-[1-phenylethyl]imidazole-4-carboxylate
PubChem CID
ChemSpider
Chemical and physical data
FormulaC16H20N2O2
Molar mass272.348 g·mol−1
3D model (JSmol)
  • O=C(C1=CN=CN1C(C2=CC=CC=C2)C)OC(C)CC
  • InChI=1S/C16H20N2O2/c1-4-12(2)20-16(19)15-10-17-11-18(15)13(3)14-8-6-5-7-9-14/h5-13H,4H2,1-3H3
  • Key:ISSGGUZEEXZEAS-UHFFFAOYSA-N

Sec-butomidate is an anesthetic drug related to etomidate, which has been sold as a designer drug as an active ingredient in e-cigarette liquids marketed under names such as space oil or kpods. It has a sec-butyl ester group in place of the ethyl ester of etomidate.1234

References

References

  1. Fan Y, Chen X, Wu H, Ke X, Chen H, Xu Y, et al. (November 2025). "Leveraging mass spectrometry fragmentation patterns for accelerated screening and structural elucidation of new etomidate analogues in suspect samples". Journal of Pharmaceutical and Biomedical Analysis. 265 117023. doi:10.1016/j.jpba.2025.117023. PMID 40532400.
  2. Bai S, Qian Z, Chen Y, Liu S, Wang F, Liu F (September 2025). "Traceability of etomidate and its analogs in biological samples using "specific" metabolites". Analytical Methods. 17 (36): 7207–7216. doi:10.1039/D5AY00773A. PMID 40879556.
  3. Bai S, Li M, Tang S, Wan S, Wu R, Chen L, et al. (2025). "Drug substitutes - Insights on benefits, risks, detection methods, and management strategies: a systematic review". Frontiers in Psychiatry. 16 1600212. doi:10.3389/fpsyt.2025.1600212. PMC 12310920. PMID 40747264.
  4. "Substance details: Sec-Butomidate". UNODC. 2025.