SAFB2

SAFB2
Identifiers
Aliases	SAFB2, scaffold attachment factor B2
External IDs	OMIM: 608066; MGI: 2146808; HomoloGene: 35210; GeneCards: SAFB2; OMA:SAFB2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,624,046 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,584,585 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; anterior pituitary; ; right uterine tube; ; left ovary; ; right ovary; ; sural nerve; ; canal of the cervix; ; body of uterus; ; right lobe of thyroid gland; ; left lobe of thyroid gland;
	Top expressed in
	neural layer of retina; ; granulocyte; ; ventricular zone; ; yolk sac; ; superior frontal gyrus; ; tail of embryo; ; thymus; ; lip; ; primary visual cortex; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleic acid binding; identical protein binding; protein binding; double-stranded DNA binding; RNA binding; sequence-specific DNA binding;
Cellular component	extracellular exosome; nucleoplasm; cytoplasm; intracellular membrane-bounded organelle; nucleus; nuclear body;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; Sertoli cell differentiation; regulation of transcription by RNA polymerase II; regulation of androgen receptor signaling pathway; regulation of mRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	9667
	224902
	ENSG00000130254
	ENSMUSG00000042625
	Q14151
	Q80YR5
	NM_014649
	NM_001029979; NM_001355463
	NP_055464
	NP_001025150; NP_001342392
	Wikidata
View/Edit Human	View/Edit Mouse

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.⁵⁶

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha⁵ and SAFB.⁵

References

GRCh38: Ensembl release 89: ENSG00000130254 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042625 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.
"Entrez Gene: SAFB2 scaffold attachment factor B2".

Further reading

Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID 14587024. S2CID 39178501.
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130254 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042625 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12660241-5] Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.

[entrez-6] "Entrez Gene: SAFB2 scaffold attachment factor B2".

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