SAA2

SAA2
Identifiers
Aliases	SAA2, serum amyloid A2, SAA1, SAA
External IDs	OMIM: 104751; MGI: 98223; GeneCards: SAA2; OMA:SAA2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,248,643 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,365,124 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; olfactory zone of nasal mucosa; ; salivary gland; ; minor salivary glands; ; lactiferous gland; ; appendix; ; subcutaneous adipose tissue; ; right adrenal cortex; ; left uterine tube; ; gastrocnemius muscle;
	Top expressed in
	ankle joint; ; left lobe of liver; ; thymus; ; thoracic diaphragm; ; stroma of bone marrow; ; white adipose tissue; ; ciliary body; ; cervix; ; retinal pigment epithelium; ; lactiferous gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	chemoattractant activity;
Cellular component	extracellular exosome; extracellular region; high-density lipoprotein particle; extracellular space;
Biological process	acute-phase response; cell chemotaxis; positive chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	6289
	20210
	ENSG00000134339
	ENSMUSG00000040026
	P0DJI9
	P04918
	NM_030754; NM_001127380
	NM_011315
	NP_001120852; NP_110381
	NP_035445
	Wikidata
View/Edit Human	View/Edit Mouse

Serum amyloid A protein is a protein that in humans is encoded by the SAA2 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000134339 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040026 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Steel DM, Sellar GC, Uhlar CM, Simon S, DeBeer FC, Whitehead AS (Jul 1993). "A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)". Genomics. 16 (2): 447–54. doi:10.1006/geno.1993.1209. PMID 7686132.
"Entrez Gene: SAA2 Serum amyloid A2".

Further reading

Betts JC, Edbrooke MR, Thakker RV, Woo P (1991). "The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells". Scand. J. Immunol. 34 (4): 471–82. doi:10.1111/j.1365-3083.1991.tb01570.x. PMID 1656519. S2CID 26076389.
Zimlichman S, Danon A, Nathan I, Mozes G, Shainkin-Kestenbaum R (1990). "Serum amyloid A, an acute phase protein, inhibits platelet activation". J. Lab. Clin. Med. 116 (2): 180–6. PMID 1697614.
Steinkasserer A, Weiss EH, Schwaeble W, Linke RP (1990). "Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis". Biochem. J. 268 (1): 187–93. doi:10.1042/bj2680187. PMC 1131410. PMID 1971508.
Woo P, Sipe J, Dinarello CA, Colten HR (1987). "Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells". J. Biol. Chem. 262 (32): 15790–5. doi:10.1016/S0021-9258(18)47798-8. PMID 2890635.
Kluve-Beckerman B, Dwulet FE, Benson MD (1988). "Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person". J. Clin. Invest. 82 (5): 1670–5. doi:10.1172/JCI113779. PMC 442736. PMID 3183061.
Kluve-Beckerman B, Long GL, Benson MD (1987). "DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA)". Biochem. Genet. 24 (11–12): 795–803. doi:10.1007/BF00554519. PMID 3800865. S2CID 8124689.
Meek RL, Hoffman JS, Benditt EP (1986). "Amyloidogenesis. One serum amyloid A isotype is selectively removed from the circulation". J. Exp. Med. 163 (3): 499–510. doi:10.1084/jem.163.3.499. PMC 2188051. PMID 3950541.
Badolato R, Wang JM, Murphy WJ, Lloyd AR, Michiel DF, Bausserman LL, Kelvin DJ, Oppenheim JJ (1994). "Serum amyloid A is a chemoattractant: induction of migration, adhesion, and tissue infiltration of monocytes and polymorphonuclear leukocytes". J. Exp. Med. 180 (1): 203–9. doi:10.1084/jem.180.1.203. PMC 2191543. PMID 7516407.
Badolato R, Johnston JA, Wang JM, McVicar D, Xu LL, Oppenheim JJ, Kelvin DJ (1995). "Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway". J. Immunol. 155 (8): 4004–10. doi:10.4049/jimmunol.155.8.4004. PMID 7561109.
Xu L, Badolato R, Murphy WJ, Longo DL, Anver M, Hale S, Oppenheim JJ, Wang JM (1995). "A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion". J. Immunol. 155 (3): 1184–90. doi:10.4049/jimmunol.155.3.1184. PMID 7636186.
Liepnieks JJ, Kluve-Beckerman B, Benson MD (1995). "Characterization of amyloid A protein in human secondary amyloidosis: the predominant deposition of serum amyloid A1". Biochim. Biophys. Acta. 1270 (1): 81–6. doi:10.1016/0925-4439(94)00076-3. PMID 7827140.
Arai K, Miura K, Baba S, Shirasawa H (1994). "Transformation from SAA2-fibrils to AA-fibrils in amyloid fibrillogenesis: in vivo observations in murine spleen using anti-SAA and anti-AA antibodies". J. Pathol. 173 (2): 127–34. doi:10.1002/path.1711730209. hdl:10271/1458. PMID 8089807. S2CID 1125165.
Meek RL, Urieli-Shoval S, Benditt EP (1994). "Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3186–90. Bibcode:1994PNAS...91.3186M. doi:10.1073/pnas.91.8.3186. PMC 43540. PMID 8159722.
Sellar GC, Jordan SA, Bickmore WA, Fantes JA, Van Heyningen V, Whitehead AS (1994). "The human serum amyloid A protein (SAA) superfamily gene cluster: mapping to chromosome 11p15.1 by physical and genetic linkage analysis". Genomics. 19 (2): 221–7. doi:10.1006/geno.1994.1051. PMID 8188252.
Ducret A, Bruun CF, Bures EJ, Marhaug G, Husby G, Aebersold R (1996). "Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry". Electrophoresis. 17 (5): 866–76. doi:10.1002/elps.1150170508. PMID 8783012. S2CID 35332525.
Ancsin JB, Kisilevsky R (1997). "Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A". J. Biol. Chem. 272 (1): 406–13. doi:10.1074/jbc.272.1.406. PMID 8995276.
Hershkoviz R, Preciado-Patt L, Lider O, Fridkin M, Dastych J, Metcalfe DD, Mekori YA (1997). "Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion". Am. J. Physiol. 273 (1 Pt 1): C179–87. doi:10.1152/ajpcell.1997.273.1.C179. PMID 9252455.
Migita K, Kawabe Y, Tominaga M, Origuchi T, Aoyagi T, Eguchi K (1998). "Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts". Lab. Invest. 78 (5): 535–9. PMID 9605178.
Urieli-Shoval S, Cohen P, Eisenberg S, Matzner Y (1999). "Widespread expression of serum amyloid A in histologically normal human tissues. Predominant localization to the epithelium". J. Histochem. Cytochem. 46 (12): 1377–84. doi:10.1177/002215549804601206. PMID 9815279.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134339 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040026 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7686132-5] Steel DM, Sellar GC, Uhlar CM, Simon S, DeBeer FC, Whitehead AS (Jul 1993). "A constitutively expressed serum amyloid A protein gene (SAA4) is closely linked to, and shares structural similarities with, an acute-phase serum amyloid A protein gene (SAA2)". Genomics. 16 (2): 447–54. doi:10.1006/geno.1993.1209. PMID 7686132.

[6] "Entrez Gene: SAA2 Serum amyloid A2".

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