S-Acylation

S-Acylation is the process of chemically linking a molecule to another molecule via a thioester bond.¹ Protein S-acylation is a sub-type of S-acylation where the first of those molecules is a protein, and connected to the second through a cysteine amino acid.¹ A prominent type of protein S-acylation is palmitoylation, which promotes lipid membrane association of the protein, for instance to the plasma membrane, Golgi apparatus, or inner nuclear membrane.²

References

Forrester, M. T.; Hess, D. T.; Thompson, J. W.; Hultman, R.; Moseley, M. A.; Stamler, J. S.; Casey, P. J. (2010). "Site-specific analysis of protein S-acylation by resin-assisted capture". The Journal of Lipid Research. 52 (2): 393–398. doi:10.1194/jlr.D011106. PMC 3023561. PMID 21044946.
Hofemeister, H.; Weber, K.; Stick, R. (2000). "Association of Prenylated Proteins with the Plasma Membrane and the Inner Nuclear Membrane is Mediated by the Same Membrane-targeting Motifs" (PDF). Molecular Biology of the Cell. 11 (9): 3233–3246. doi:10.1091/mbc.11.9.3233. PMC 14988. PMID 10982413.

[first-1] Forrester, M. T.; Hess, D. T.; Thompson, J. W.; Hultman, R.; Moseley, M. A.; Stamler, J. S.; Casey, P. J. (2010). "Site-specific analysis of protein S-acylation by resin-assisted capture". The Journal of Lipid Research. 52 (2): 393–398. doi:10.1194/jlr.D011106. PMC 3023561. PMID 21044946.

[2] Hofemeister, H.; Weber, K.; Stick, R. (2000). "Association of Prenylated Proteins with the Plasma Membrane and the Inner Nuclear Membrane is Mediated by the Same Membrane-targeting Motifs" (PDF). Molecular Biology of the Cell. 11 (9): 3233–3246. doi:10.1091/mbc.11.9.3233. PMC 14988. PMID 10982413.

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