RWDD3

RWDD3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EBK, 4Y1L
Identifiers
Aliases	RWDD3, RSUME, RWD domain containing 3
External IDs	OMIM: 615875; MGI: 1920420; HomoloGene: 22899; GeneCards: RWDD3; OMA:RWDD3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	95,247,225 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	120,965,344 bp
RNA expression pattern
	Top expressed in
	endometrium; ; body of pancreas; ; Achilles tendon; ; right lobe of liver; ; nucleus accumbens; ; amygdala; ; putamen; ; olfactory zone of nasal mucosa; ; caudate nucleus; ; corpus callosum;
	Top expressed in
	medial ganglionic eminence; ; lumbar subsegment of spinal cord; ; supraoptic nucleus; ; arcuate nucleus; ; ventromedial nucleus; ; dentate gyrus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; median eminence; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; nucleus;
Biological process	negative regulation of NF-kappaB transcription factor activity; positive regulation of protein sumoylation; positive regulation of hypoxia-inducible factor-1alpha signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	25950
	66568
	ENSG00000122481
	ENSMUSG00000028133
	Q9Y3V2
	Q8VIL2
	NM_001128142; NM_001199682; NM_001278247; NM_001278248; NM_015485
	NM_025637; NM_028456
	NP_001121614; NP_001186611; NP_001265176; NP_001265177; NP_056300
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

RWD domain-containing protein 3 is a protein that in humans is encoded by the RWDD3 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000122481 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028133 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
"Entrez Gene: RWDD3 RWD domain containing 3".

Further reading

Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. (2008). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". Cell. 131 (2): 309–23. doi:10.1016/j.cell.2007.07.044. hdl:20.500.12110/paper_00928674_v131_n2_p309_CarbiaNagashima. PMID 17956732. S2CID 12486303.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122481 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028133 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: RWDD3 RWD domain containing 3".

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