RSF1

RSF1
Identifiers
Aliases	RSF1, HBXAP, RSF-1, XAP8, p325, remodeling and spacing factor 1
External IDs	OMIM: 608522; MGI: 2682305; HomoloGene: 41142; GeneCards: RSF1; OMA:RSF1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,820,869 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,341,985 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; internal globus pallidus; ; sural nerve; ; epithelium of colon; ; tendon of biceps brachii; ; cerebellar vermis; ; Brodmann area 23; ; pars reticulata; ; middle temporal gyrus; ; external globus pallidus;
	Top expressed in
	hand; ; Rostral migratory stream; ; tail of embryo; ; genital tubercle; ; ventromedial nucleus; ; lateral septal nucleus; ; otolith organ; ; olfactory tubercle; ; utricle; ; maxillary prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone binding; ATPase activity; protein binding; metal ion binding; histone acetyltransferase activity;
Cellular component	RSF complex; nucleus; nucleoplasm; histone acetyltransferase complex;
Biological process	positive regulation of transcription, DNA-templated; negative regulation of DNA binding; chromatin remodeling; positive regulation of viral transcription; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; CENP-A containing chromatin assembly; transcription, DNA-templated; DNA-templated transcription, initiation; nucleosome assembly; chromatin organization; histone acetylation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	51773
	233532
	ENSG00000048649
	ENSMUSG00000035623
	Q96T23; Q05DG0
	n/a
	NM_016578
	NM_001081267
	NP_057662; NP_057662.3
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.⁵⁶⁷

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]⁷

References

GRCh38: Ensembl release 89: ENSG00000048649 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035623 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (Mar 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J Biol Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Sep 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
"Entrez Gene: RSF1 remodeling and spacing factor 1".

Further reading

Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein". J. Virol. 69 (2): 1107–14. doi:10.1128/JVI.69.2.1107-1114.1995. PMC 188683. PMID 7815490.
LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science. 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity". Genomics. 79 (4): 523–9. doi:10.1006/geno.2002.6717. PMID 11944984.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB". Exp. Cell Res. 298 (1): 133–43. doi:10.1016/j.yexcr.2004.04.019. PMID 15242768.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. Bibcode:2005PNAS..10214004S. doi:10.1073/pnas.0504195102. PMC 1236547. PMID 16172393.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000048649 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035623 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11788598-5] Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (Mar 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J Biol Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.

[pmid12972596-6] Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Sep 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.

[entrez-7] "Entrez Gene: RSF1 remodeling and spacing factor 1".

1

2

3

4

5

6

7