RPS6KA5

RPS6KA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VZO, 3KN5, 3KN6
Identifiers
Aliases	RPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
External IDs	OMIM: 603607; MGI: 1920336; HomoloGene: 48302; GeneCards: RPS6KA5; OMA:RPS6KA5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	91,060,641 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	100,693,242 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tail of epididymis; ; nipple; ; corpus callosum; ; inferior ganglion of vagus nerve; ; buccal mucosa cell; ; Brodmann area 23; ; pons; ; bronchial epithelial cell; ; Skeletal muscle tissue of biceps brachii;
	Top expressed in
	dorsal striatum; ; zygote; ; olfactory tubercle; ; secondary oocyte; ; lobe of cerebellum; ; cerebellar vermis; ; nucleus accumbens; ; gastrula; ; subiculum; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; metal ion binding; kinase activity; protein binding; ATP binding; magnesium ion binding; protein serine/threonine kinase activity;
Cellular component	cytoplasm; nucleoplasm; nucleus;
Biological process	intracellular signal transduction; regulation of transcription, DNA-templated; epidermal growth factor receptor signaling pathway; phosphorylation; stimulatory C-type lectin receptor signaling pathway; axon guidance; positive regulation of histone acetylation; interleukin-1-mediated signaling pathway; protein phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; inflammatory response; negative regulation of transcription, DNA-templated; negative regulation of cytokine production; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	9252
	73086
	ENSG00000100784
	ENSMUSG00000021180
	O75582
	Q8C050
NM_004755; NM_182398; NM_001322227; NM_001322228; NM_001322229;
	NM_001322230; NM_001322231; NM_001322232; NM_001322233; NM_001322234; NM_001322235; NM_001322236; NM_001322237; NM_001322238
	NM_153587; NM_001330702
NP_001309156; NP_001309157; NP_001309158; NP_001309159; NP_001309160;
	NP_001309161; NP_001309162; NP_001309163; NP_001309164; NP_001309165; NP_001309166; NP_001309167; NP_004746; NP_872198
	NP_001317631; NP_705815
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.⁵⁶⁷ This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.⁸⁹

Interactions

RPS6KA5 has been shown to interact with CREB1.⁵¹⁰

References

GRCh38: Ensembl release 89: ENSG00000100784 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021180 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 87 (3–4): 261–262. doi:10.1159/000015441. PMID 10702687. S2CID 10527498.
"Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".
Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, et al. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. ISSN 0261-4189. PMC 156769. PMID 12773393.
Reul JM, Chandramohan Y (2007-08-01). "Epigenetic mechanisms in stress-related memory formation". Psychoneuroendocrinology. Integrative approaches to neural plasticity (Lille Summer School, 2006). 32 Suppl 1: S21–S25. doi:10.1016/j.psyneuen.2007.03.016. ISSN 0306-4530. PMID 17644269. S2CID 24217924.
Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". The EMBO Journal. 20 (16): 4370–4379. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

Further reading

Chung J, Uchida E, Grammer TC, Blenis J (Nov 1997). "STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation". Molecular and Cellular Biology. 17 (11): 6508–6516. doi:10.1128/MCB.17.11.6508. PMC 232504. PMID 9343414.
Jain N, Zhang T, Fong SL, Lim CP, Cao X (Dec 1998). "Repression of Stat3 activity by activation of mitogen-activated protein kinase (MAPK)". Oncogene. 17 (24): 3157–3167. doi:10.1038/sj.onc.1202238. PMID 9872331.
New L, Zhao M, Li Y, Bassett WW, Feng Y, Ludwig S, et al. (Jan 1999). "Cloning and characterization of RLPK, a novel RSK-related protein kinase". Journal of Biological Chemistry. 274 (2): 1026–1032. doi:10.1074/jbc.274.2.1026. PMID 9873047.
Thomson S, Clayton AL, Hazzalin CA, Rose S, Barratt MJ, Mahadevan LC (Sep 1999). "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase". The EMBO Journal. 18 (17): 4779–4793. doi:10.1093/emboj/18.17.4779. PMC 1171550. PMID 10469656.
Lim CP, Cao X (Oct 1999). "Serine phosphorylation and negative regulation of Stat3 by JNK". Journal of Biological Chemistry. 274 (43): 31055–31061. doi:10.1074/jbc.274.43.31055. PMID 10521505.
Buck M, Poli V, Geer P, Chojkier M, Hunter T (Dec 1999). "Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha". Molecular Cell. 4 (6): 1087–1092. doi:10.1016/S1097-2765(00)80237-3. PMID 10635333.
Lizcano JM, Morrice N, Cohen P (Jul 2000). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". The Biochemical Journal. 349 (Pt 2): 547–557. doi:10.1042/0264-6021:3490547. PMC 1221178. PMID 10880354.
Hefner Y, Borsch-Haubold AG, Murakami M, Wilde JI, Pasquet S, Schieltz D, et al. (Dec 2000). "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases". Journal of Biological Chemistry. 275 (48): 37542–37551. doi:10.1074/jbc.M003395200. PMID 10978317.
Arthur JS, Cohen P (Sep 2000). "MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells". FEBS Letters. 482 (1–2): 44–48. Bibcode:2000FEBSL.482...44A. doi:10.1016/S0014-5793(00)02031-7. PMID 11018520.
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, et al. (Jun 2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth". Journal of Biological Chemistry. 276 (22): 19469–19482. doi:10.1074/jbc.M009953200. PMID 11297520.
Deb A, Zamanian-Daryoush M, Xu Z, Kadereit S, Williams BR (May 2001). "Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3". The EMBO Journal. 20 (10): 2487–2496. doi:10.1093/emboj/20.10.2487. PMC 125453. PMID 11350938.
Liu G, Zhang Y, Bode AM, Ma WY, Dong Z (Mar 2002). "Phosphorylation of 4E-BP1 is mediated by the p38/MSK1 pathway in response to UVB irradiation". Journal of Biological Chemistry. 277 (11): 8810–8816. doi:10.1074/jbc.M110477200. PMID 11777913.
Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS (Apr 2002). "MSK1 and MSK2 Are Required for the Mitogen- and Stress-Induced Phosphorylation of CREB and ATF1 in Fibroblasts". Molecular and Cellular Biology. 22 (8): 2871–2881. doi:10.1128/MCB.22.8.2871-2881.2002. PMC 133730. PMID 11909979.
Markou T, Lazou A (Aug 2002). "Phosphorylation and activation of mitogen- and stress-activated protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled receptor agonists requires both extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase". The Biochemical Journal. 365 (Pt 3): 757–763. doi:10.1042/BJ20011828. PMC 1222733. PMID 11994045.
Toska K, Kleppe R, Armstrong CG, Morrice NA, Cohen P, Haavik J (Nov 2002). "Regulation of tyrosine hydroxylase by stress-activated protein kinases". Journal of Neurochemistry. 83 (4): 775–783. doi:10.1046/j.1471-4159.2002.01172.x. PMID 12421349.
Janknecht R (Feb 2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746–755. doi:10.1038/sj.onc.1206185. PMID 12569367. S2CID 30183941.
Dolled-Filhart M, Camp RL, Kowalski DP, Smith BL, Rimm DL (Feb 2003). "Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis". Clinical Cancer Research. 9 (2): 594–600. PMID 12576423.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100784 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021180 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Deak_1998-5] Deak M, Clifton AD, Lucocq LM, Alessi DR (September 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–4441. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.

[Jiang_2000-6] Jiang C, Yu L, Tu Q, Zhao Y, Zhang H, Zhao S (April 2000). "Assignment of a member of the ribosomal protein S6 kinase family, RPS6KA5, to human chromosome 14q31→q32.1 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 87 (3–4): 261–262. doi:10.1159/000015441. PMID 10702687. S2CID 10527498.

[entrez-7] "Entrez Gene: RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5".

[8] Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, et al. (2003-06-02). "MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14". The EMBO Journal. 22 (11): 2788–2797. doi:10.1093/emboj/cdg273. ISSN 0261-4189. PMC 156769. PMID 12773393.

[9] Reul JM, Chandramohan Y (2007-08-01). "Epigenetic mechanisms in stress-related memory formation". Psychoneuroendocrinology. Integrative approaches to neural plasticity (Lille Summer School, 2006). 32 Suppl 1: S21–S25. doi:10.1016/j.psyneuen.2007.03.016. ISSN 0306-4530. PMID 17644269. S2CID 24217924.

[Wang_2001-10] Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (August 2001). "Regulation of elongation factor 2 kinase by p90RSK1 and p70 S6 kinase". The EMBO Journal. 20 (16): 4370–4379. doi:10.1093/emboj/20.16.4370. ISSN 0261-4189. PMC 125559. PMID 11500364.

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