Article · Wikipedia archive · Last revised Jul 27, 2026

Rhea (database)

Rhea is a database of biochemical reactions maintained by the Swiss Institute of Bioinformatics (SIB). It provides standardized reaction equations using ChEBI structured, controlled chemical vocabulary. It serves as a reference resource for enzymes and transporters. Rhea is integrated with major biological databases including UniProt, Gene Ontology, and ExPASy. It supports searching by EC number and chemical identifiers.

Last revised
Jul 27, 2026
Read time
≈ 1 min
Length
141 w
Citations
2
Source
Wikipedia ↗
Rhea
Content
DescriptionExpertly curated biochemical reaction database
Contact
Research centerSwiss Institute of Bioinformatics (SIB)
Primary citationPMID 34755880
Release date2012
Access
Websitehttps://www.rhea-db.org
Download URLDownload Rhea
Web service URLREST API
Sparql endpointSPARQL endpoint

Rhea is a database of biochemical reactions maintained by the Swiss Institute of Bioinformatics (SIB). It provides standardized reaction equations using ChEBI structured, controlled chemical vocabulary. It serves as a reference resource for enzymes and transporters. Rhea is integrated with major biological databases including UniProt, Gene Ontology, and ExPASy. It supports searching by EC number and chemical identifiers.12

References

References

  1. Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, et al. (January 2022). "Rhea, the reaction knowledgebase in 2022". Nucleic Acids Research. 50 (D1): D693–D700. doi:10.1093/nar/gkab1016. PMC 8728268. PMID 34755880.
  2. Prešern U, Goličnik M (November 2023). "Enzyme Databases in the Era of Omics and Artificial Intelligence". International Journal of Molecular Sciences. 24 (23) 16918. doi:10.3390/ijms242316918. PMC 10707154. PMID 38069254.