REXO4

REXO4
Identifiers
Aliases	REXO4, REX4, XPMC2, XPMC2H, REX4 homolog, 3'-5' exonuclease
External IDs	OMIM: 602930; MGI: 2684957; HomoloGene: 133948; GeneCards: REXO4; OMA:REXO4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,418,096 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,854,398 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; skeletal muscle tissue; ; gastrocnemius muscle; ; muscle of thigh; ; mucosa of transverse colon; ; ventricular zone; ; granulocyte; ; ganglionic eminence; ; apex of heart; ; body of pancreas;
	Top expressed in
	Paneth cell; ; fossa; ; condyle; ; internal carotid artery; ; external carotid artery; ; thymus; ; neural layer of retina; ; motor neuron; ; medullary collecting duct; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; nuclease activity; exonuclease activity; hydrolase activity; nucleic acid binding; RNA binding; single-stranded DNA binding; transcription coactivator activity; endonuclease activity; 3'-5' exonuclease activity;
Cellular component	nucleolus; nucleus; nuclear speck;
Biological process	regulation of transcription, DNA-templated; nucleic acid phosphodiester bond hydrolysis; DNA catabolic process, endonucleolytic; DNA catabolic process, exonucleolytic; rRNA processing; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	57109
	227656
	ENSG00000280706; ENSG00000148300
	ENSMUSG00000052406
	Q9GZR2
	Q6PAQ4
	NM_001279349; NM_001279350; NM_001279351; NM_020385
	NM_207234; NM_001362876
	NP_001266278; NP_001266279; NP_001266280; NP_065118
	NP_997117; NP_001349805
	Wikidata
View/Edit Human	View/Edit Mouse

RNA exonuclease 4 is an enzyme that in humans is encoded by the REXO4 gene.⁵⁶

References

ENSG00000148300 GRCh38: Ensembl release 89: ENSG00000280706, ENSG00000148300 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000052406 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ (Nov 1997). "Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1". Genomics. 44 (3): 350–4. doi:10.1006/geno.1997.4874. PMID 9325058.
"Entrez Gene: REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)".

Further reading

Montano MM, Wittmann BM, Bianco NR (2000). "Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity". J. Biol. Chem. 275 (44): 34306–13. doi:10.1074/jbc.M003880200. PMID 10908561.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] ENSG00000148300 GRCh38: Ensembl release 89: ENSG00000280706, ENSG00000148300 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052406 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9325058-5] Kwiatkowska J, Slomski R, Jozwiak S, Short MP, Kwiatkowski DJ (Nov 1997). "Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1". Genomics. 44 (3): 350–4. doi:10.1006/geno.1997.4874. PMID 9325058.

[entrez-6] "Entrez Gene: REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)".

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