REPS2

REPS2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IQ3
Identifiers
Aliases	REPS2, POB1, RALBP1 associated Eps domain containing 2
External IDs	OMIM: 300317; MGI: 2663511; HomoloGene: 31255; GeneCards: REPS2; OMA:REPS2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	17,153,272 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	161,426,645 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; corpus epididymis; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; postcentral gyrus; ; sural nerve; ; superior frontal gyrus; ; blood; ; pons; ; corpus callosum;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; subiculum; ; olfactory tubercle; ; primary motor cortex; ; mammillary body; ; anterior amygdaloid area; ; inferior colliculi; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; protein binding; metal ion binding;
Cellular component	cytoplasm; cytosol;
Biological process	epidermal growth factor receptor signaling pathway; membrane organization; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	9185
	194590
	ENSG00000169891
	ENSMUSG00000040855
	Q8NFH8
	Q80XA6
	NM_001080975; NM_004726
	NM_001290633; NM_178256; NM_001359102; NM_001359103; NM_001359104
	NP_001074444; NP_004717
NP_001277562; NP_839987; NP_001346031; NP_001346032; NP_001346033;
	NP_001390994; NP_001390995; NP_001390996; NP_001390997; NP_001390998
	Wikidata
View/Edit Human	View/Edit Mouse

RalBP1-associated Eps domain-containing protein 2 is a protein that in humans is encoded by the REPS2 gene.⁵⁶⁷

Function

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.⁷

Interactions

REPS2 has been shown to interact with EPN1,⁸ EPS15⁹ and RALBP1.⁵

References

GRCh38: Ensembl release 89: ENSG00000169891 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000040855 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (February 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J Biol Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.
Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S (February 1999). "Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)". FEBS Lett. 442 (2–3): 138–42. Bibcode:1999FEBSL.442..138K. doi:10.1016/S0014-5793(98)01644-5. PMID 9928989.
"Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2".
Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (October 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. S2CID 23390428.
Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (July 1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441. PMID 10393179.

Further reading

Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441. PMID 10393179.
Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. S2CID 23390428.
Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
Oshiro T, Koyama S, Sugiyama S, Kondo A, Onodera Y, Asahara T, Sabe H, Kikuchi A (2002). "Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration". J. Biol. Chem. 277 (41): 38618–26. doi:10.1074/jbc.M203453200. PMID 12149250.
Oosterhoff JK, Penninkhof F, Brinkmann AO, Anton Grootegoed J, Blok LJ (2003). "REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells". Oncogene. 22 (19): 2920–5. doi:10.1038/sj.onc.1206397. PMID 12771942. S2CID 22877286.
Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (2003). "RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis". J. Biol. Chem. 278 (33): 30597–604. doi:10.1074/jbc.M302191200. PMID 12775724.
Penninkhof F, Grootegoed JA, Blok LJ (2004). "Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells" (PDF). Oncogene. 23 (33): 5607–15. doi:10.1038/sj.onc.1207750. hdl:1765/73476. PMID 15184881.
Oosterhoff JK, Kühne LC, Grootegoed JA, Blok LJ (2005). "EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2". Int. J. Cancer. 113 (4): 561–7. doi:10.1002/ijc.20612. PMID 15455380. S2CID 6956264.
Yadav S, Zajac E, Singhal SS, Singhal J, Drake K, Awasthi YC, Awasthi S (2005). "POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis". Biochem. Biophys. Res. Commun. 328 (4): 1003–9. Bibcode:2005BBRC..328.1003Y. doi:10.1016/j.bbrc.2005.01.055. PMID 15707977.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169891 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9422736-5] Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A (February 1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J Biol Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.

[pmid9928989-6] Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S (February 1999). "Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1)". FEBS Lett. 442 (2–3): 138–42. Bibcode:1999FEBSL.442..138K. doi:10.1016/S0014-5793(98)01644-5. PMID 9928989.

[entrez-7] "Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2".

[pmid10557078-8] Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (October 1999). "Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis". Oncogene. 18 (43): 5915–22. doi:10.1038/sj.onc.1202974. PMID 10557078. S2CID 23390428.

[pmid10393179-9] Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A (July 1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMC 1171441. PMID 10393179.

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