RBBP9

RBBP9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QS9
Identifiers
Aliases	RBBP9, BOG, RBBP10, retinoblastoma binding protein 9, RB binding protein 9, serine hydrolase
External IDs	OMIM: 602908; MGI: 1347074; HomoloGene: 4816; GeneCards: RBBP9; OMA:RBBP9 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	18,497,225 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	144,392,789 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; olfactory zone of nasal mucosa; ; bronchial epithelial cell; ; ventricular zone; ; skin of thigh; ; ganglionic eminence; ; mucosa of paranasal sinus; ; stromal cell of endometrium; ; palpebral conjunctiva; ; endothelial cell;
	Top expressed in
	vestibular sensory epithelium; ; right kidney; ; left lung lobe; ; tail of embryo; ; olfactory epithelium; ; epithelium of lens; ; seminal vesicula; ; genital tubercle; ; sciatic nerve; ; ventricular zone;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; hydrolase activity;
Cellular component	nucleus; nucleoplasm; cytoplasm;
Biological process	regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	10741
	26450
	ENSG00000089050
	ENSMUSG00000027428
	O75884
	O88851
	NM_006606; NM_153328
	NM_015754
	NP_006597
	NP_056569
	Wikidata
View/Edit Human	View/Edit Mouse

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.⁵⁶⁷

Function

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.⁷

Interactions

RBBP9 has been shown to interact with Retinoblastoma protein.⁵

References

GRCh38: Ensembl release 89: ENSG00000089050 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027428 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699. S2CID 11374970.
Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 252–3. doi:10.1159/000015304. PMID 10449909. S2CID 21843409.
"Entrez Gene: RBBP9 retinoblastoma binding protein 9".

Further reading

Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM (Aug 2002). "Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10". Biochemical Genetics. 40 (7–8): 273–82. doi:10.1023/A:1019886918029. PMID 12296629. S2CID 8381137.
Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y (2003). "Isolation and identification of a novel cDNA that encodes human yrdC protein". Journal of Human Genetics. 48 (4): 164–9. doi:10.1007/s10038-002-0001-3. PMID 12730717.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000089050 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027428 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9697699-5] Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): 371–4. doi:10.1038/1258. PMID 9697699. S2CID 11374970.

[pmid10449909-6] Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 252–3. doi:10.1159/000015304. PMID 10449909. S2CID 21843409.

[entrez-7] "Entrez Gene: RBBP9 retinoblastoma binding protein 9".

1

2

3

4

5

6

7