RAP1GDS1

RAP1GDS1
Identifiers
Aliases	RAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDs	OMIM: 179502; MGI: 2385189; HomoloGene: 41422; GeneCards: RAP1GDS1; OMA:RAP1GDS1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	98,443,861 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	138,780,962 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; pons; ; pars compacta; ; trigeminal ganglion; ; pars reticulata; ; middle temporal gyrus; ; spinal ganglia; ; superior vestibular nucleus; ; sperm; ; corpus callosum;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; perirhinal cortex; ; inferior colliculi; ; olfactory epithelium; ; visual cortex; ; pontine nuclei; ; primary motor cortex; ; CA3 field;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity;
Cellular component	cytosol; extracellular exosome; endoplasmic reticulum; mitochondrion;
Biological process	negative regulation of endoplasmic reticulum calcium ion concentration; positive regulation of mitochondrial calcium ion concentration; vascular associated smooth muscle contraction; myosin filament assembly; small GTPase mediated signal transduction; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	5910
	229877
	ENSG00000138698
	ENSMUSG00000028149
	P52306
	E9Q912
NM_001100426; NM_001100427; NM_001100428; NM_001100429; NM_001100430;
	NM_021159
	NM_001040690; NM_001286759; NM_145544; NM_001356388
NP_001093896; NP_001093897; NP_001093898; NP_001093899; NP_001093900;
	NP_066982
	NP_001035780; NP_001273688; NP_001343317; NP_663519
	Wikidata
View/Edit Human	View/Edit Mouse

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.⁵⁶⁷

Interactions

RAP1GDS1 has been shown to interact with KIFAP3,⁸ HRAS⁹ and RHOA.⁹

References

GRCh38: Ensembl release 89: ENSG00000138698 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028149 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526. S2CID 21189125.
Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.
"Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.
Vikis HG, Stewart Scott, Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427. S2CID 6647800.

Further reading

Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21". Oncogene. 7 (2): 289–93. PMID 1549351.
Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189.
Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. PMID 11948427. S2CID 6647800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes". J. Biol. Chem. 278 (25): 22412–7. doi:10.1074/jbc.M212036200. PMID 12690117.
Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis". Blood. 103 (7): 2661–7. doi:10.1182/blood-2003-06-2154. PMID 14615375.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138698 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8262526-5] Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526. S2CID 21189125.

[pmid17951244-6] Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.

[entrez-7] "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".

[pmid8900189-8] Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.

[pmid11948427-9] Vikis HG, Stewart Scott, Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427. S2CID 6647800.

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