Article · Wikipedia archive · Last revised Jul 23, 2026

Ralaniten

Ralaniten is an N-terminal domain antiandrogen which was never marketed. It is a derivative of bisphenol A and one of the four stereoisomers of EPI-001. A prodrug of ralaniten, ralaniten acetate (EPI-506), was under development for the treatment of prostate cancer.

Last revised
Jul 23, 2026
Read time
≈ 1 min
Length
175 w
Citations
4
Source
Wikipedia ↗
Ralaniten
Clinical data
Other namesEPI-002
Drug classNonsteroidal antiandrogen
Identifiers
  • (2R)-3-[4-[2-[4-[(2S)-3-Chloro-2-hydroxypropoxy]phenyl]propan-2-yl]phenoxy]propane-1,2-diol
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC21H27ClO5
Molar mass394.89 g·mol−1
3D model (JSmol)
  • CC(C)(C1=CC=C(C=C1)OC[C@@H](CO)O)C2=CC=C(C=C2)OC[C@@H](CCl)O
  • InChI=1S/C21H27ClO5/c1-21(2,15-3-7-19(8-4-15)26-13-17(24)11-22)16-5-9-20(10-6-16)27-14-18(25)12-23/h3-10,17-18,23-25H,11-14H2,1-2H3/t17-,18-/m1/s1
  • Key:HDTYUHNZRYZEEB-QZTJIDSGSA-N

Ralaniten (developmental code name EPI-002) is an N-terminal domain antiandrogen which was never marketed.1 It is a derivative of bisphenol A2 and one of the four stereoisomers of EPI-001.1 A prodrug of ralaniten, ralaniten acetate (EPI-506), was under development for the treatment of prostate cancer.3

See also

See also

References

References

  1. Myung JK, Banuelos CA, Fernandez JG, Mawji NR, Wang J, Tien AH, et al. (July 2013). "An androgen receptor N-terminal domain antagonist for treating prostate cancer". The Journal of Clinical Investigation. 123 (7): 2948–2960. doi:10.1172/JCI66398. PMC 3696543. PMID 23722902.
  2. Monaghan AE, McEwan IJ (2016). "A sting in the tail: the N-terminal domain of the androgen receptor as a drug target". Asian Journal of Andrology. 18 (5): 687–694. doi:10.4103/1008-682X.181081. PMC 5000789. PMID 27212126.
  3. Maughan BL, Antonarakis ES (December 2015). "Clinical Relevance of Androgen Receptor Splice Variants in Castration-Resistant Prostate Cancer". Current Treatment Options in Oncology. 16 (12): 57. doi:10.1007/s11864-015-0375-z. PMID 26537882. S2CID 30398927.