RAB3C

RAB3C
Identifiers
Aliases	RAB3C, member RAS oncogene family
External IDs	OMIM: 612829; MGI: 1914545; HomoloGene: 23420; GeneCards: RAB3C; OMA:RAB3C - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	58,859,394 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	110,417,530 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; pars compacta; ; pars reticulata; ; Brodmann area 46; ; middle temporal gyrus; ; superior frontal gyrus; ; Brodmann area 23; ; superior vestibular nucleus; ; islet of Langerhans; ; postcentral gyrus;
	Top expressed in
	medial dorsal nucleus; ; ventral tegmental area; ; medial geniculate nucleus; ; subiculum; ; lateral geniculate nucleus; ; superior colliculus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; dorsal tegmental nucleus; ; anterior amygdaloid area;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; myosin V binding; protein binding; GTP-dependent protein binding; GTPase activity;
Cellular component	perinuclear region of cytoplasm; vesicle; cytosol; plasma membrane; membrane; synaptic vesicle; anchored component of synaptic vesicle membrane; endosome;
Biological process	regulation of exocytosis; protein transport; antigen processing and presentation; intracellular protein transport; vesicle docking involved in exocytosis; protein secretion; Rab protein signal transduction; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	115827
	67295
	ENSG00000152932
	ENSMUSG00000021700
	Q96E17
	P62823
	NM_138453; NM_001317915
	NM_023852; NM_001360099
	NP_001304844; NP_612462
	NP_076341; NP_001347028
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.⁵⁶

Interactions

Rab3C has been shown to interact with ZWINT.⁷

References

GRCh38: Ensembl release 89: ENSG00000152932 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021700 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics. 40 (7–8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628. S2CID 10653465.
"Entrez Gene: RAB3C RAB3C, member RAS oncogene family".
van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232. S2CID 30206840.

Further reading

Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (Jun 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
Fukuda M (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Schlüter OM, Khvotchev M, Jahn R, Südhof TC (Oct 2002). "Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion". The Journal of Biological Chemistry. 277 (43): 40919–29. doi:10.1074/jbc.M203704200. PMID 12167638.
Uphues I, Chern Y, Eckel J (Dec 1995). "Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats". FEBS Letters. 377 (2): 109–12. doi:10.1016/0014-5793(95)01315-6. PMID 8543030. S2CID 27119138.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152932 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021700 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12296628-5] Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics. 40 (7–8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628. S2CID 10653465.

[entrez-6] "Entrez Gene: RAB3C RAB3C, member RAS oncogene family".

[pmid18625232-7] van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232. S2CID 30206840.

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