Article · Wikipedia archive · Last revised Jun 18, 2026

Protodesnitazene

Protodesnitazene is a benzimidazole derivative which has been sold as a designer drug, and has potent opioid effects. It has been identified in Canada, Australia, the United Kingdom and Finland, first appearing in early 2025.

Last revised
Jun 18, 2026
Read time
≈ 1 min
Length
262 w
Citations
8
Source
Wikipedia ↗
Protodesnitazene
Identifiers
  • N,N-diethyl-2-[2-[(4-propoxyphenyl)methyl]benzimidazol-1-yl]ethanamine
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC23H31N3O
Molar mass365.521 g·mol−1
3D model (JSmol)
  • CCCOC1=CC=C(C=C1)CC2=NC3=CC=CC=C3N2CCN(CC)CC
  • InChI=1S/C23H31N3O/c1-4-17-27-20-13-11-19(12-14-20)18-23-24-21-9-7-8-10-22(21)26(23)16-15-25(5-2)6-3/h7-14H,4-6,15-18H2,1-3H3
  • Key:CEHFMRGBRNNSCM-UHFFFAOYSA-N

Protodesnitazene is a benzimidazole derivative which has been sold as a designer drug, and has potent opioid effects. It has been identified in Canada, Australia, the United Kingdom and Finland, first appearing in early 2025.12345678

See also

See also

References

References

  1. "High Risk Substance Detected In Fentanyl Trafficking Investigation". Sarnia Police Service. 13 March 2025. Retrieved 17 August 2025.
  2. "Fredericton Police Warn of New, Potentially Fatal Street Drug". City of Fredericton. Fredericton Police. 9 April 2025. Retrieved 17 August 2025.
  3. "New nitazene (strong opioid) Protodesnitazene detected" (PDF). Queensland Health. Queensland Government. March 2025. Retrieved 17 August 2025.
  4. Gwynn L (4 April 2025). "Nitazines found in black market vapes as criminals make new variations to evade detection". ABC News. Australian Broadcasting Corporation. Retrieved 17 August 2025.
  5. "Rapid Action Drug Alerts and Response (RADAR) Alert: Nitazenes". Public Health Scotland. NHS Scotland. 12 August 2025. Retrieved 17 August 2025.
  6. "Customs warns about an extremely dangerous substance in the drug trade". Finnish Customs. 20 October 2025. Retrieved 22 August 2025.
  7. Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, et al. (August 2025). "A putative binding model of nitazene derivatives at the μ-opioid receptor". Neuropharmacology. 273 110437. doi:10.1016/j.neuropharm.2025.110437. PMC 12279083. PMID 40185362.
  8. Hardwick EK, Couch AN, Davidson JT (March 2026). "Comparison of Activation Techniques for the Identification of Nitazene Analogs Using the NIST/NIJ Data Interpretation Tool". Rapid Communications in Mass Spectrometry. 40 (5) e70004. doi:10.1002/rcm.70004. PMID 41359886.