PRMT3

PRMT3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FYT, 3SMQ, 4HSG, 4QQN, 4RYL
Identifiers
Aliases	PRMT3, HRMT1L3, protein arginine methyltransferase 3
External IDs	OMIM: 603190; MGI: 1919224; HomoloGene: 24255; GeneCards: PRMT3; OMA:PRMT3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	20,509,338 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	49,508,013 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; Achilles tendon; ; gonad; ; gingival epithelium; ; gastrocnemius muscle; ; left lobe of thyroid gland; ; germinal epithelium; ; right lobe of thyroid gland; ; islet of Langerhans; ; C1 segment;
	Top expressed in
	genital tubercle; ; tail of embryo; ; condyle; ; cumulus cell; ; fossa; ; substantia nigra; ; Paneth cell; ; primitive streak; ; endothelial cell of lymphatic vessel; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; methyltransferase activity; transferase activity; protein binding; protein-arginine N-methyltransferase activity; nucleic acid binding; histone-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; ribosome binding;
Cellular component	ribosome; cytoplasm; cytosol; nucleus;
Biological process	methylation; negative regulation of protein ubiquitination; peptidyl-arginine N-methylation; protein methylation; regulation of transcription, DNA-templated; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; histone arginine methylation;
	Sources:Amigo / QuickGO
Orthologs
	10196
	71974
	ENSG00000185238
	ENSMUSG00000030505
	O60678
	Q922H1
	NM_001145166; NM_001145167; NM_005788
	NM_133740
	NP_001138638; NP_001138639; NP_005779
	NP_598501
	Wikidata
View/Edit Human	View/Edit Mouse

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene.⁵⁶

Interactions

PRMT3 has been shown to interact with RPS2.⁷

References

GRCh38: Ensembl release 89: ENSG00000185238 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000030505 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tang J, Gary JD, Clarke S, Herschman HR (July 1998). "PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation". The Journal of Biological Chemistry. 273 (27): 16935–45. doi:10.1074/jbc.273.27.16935. PMID 9642256.
"Entrez Gene: PRMT3 protein arginine methyltransferase 3".
Choi S, Jung CR, Kim JY, Im DS (September 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochimica et Biophysica Acta (BBA) - General Subjects. 1780 (9): 1062–9. doi:10.1016/j.bbagen.2008.05.010. PMID 18573314.

External links

PRMT3 human gene location in the UCSC Genome Browser.
PRMT3 human gene details in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185238 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030505 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9642256-5] Tang J, Gary JD, Clarke S, Herschman HR (July 1998). "PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation". The Journal of Biological Chemistry. 273 (27): 16935–45. doi:10.1074/jbc.273.27.16935. PMID 9642256.

[entrez-6] "Entrez Gene: PRMT3 protein arginine methyltransferase 3".

[pmid18573314-7] Choi S, Jung CR, Kim JY, Im DS (September 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochimica et Biophysica Acta (BBA) - General Subjects. 1780 (9): 1062–9. doi:10.1016/j.bbagen.2008.05.010. PMID 18573314.

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Interactions

References

Further reading

External links