PPP3CA

PPP3CA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73, 3LL8, 4F0Z, 4Q5U, 5C1V
Identifiers
Aliases	PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B, protein phosphatase 3 catalytic subunit alpha, IECEE, IECEE1, ACCIID, DEE91
External IDs	OMIM: 114105; MGI: 107164; HomoloGene: 55497; GeneCards: PPP3CA; OMA:PPP3CA - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	101,348,278 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	136,643,488 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; middle temporal gyrus; ; Region I of hippocampus proper; ; postcentral gyrus; ; Brodmann area 46; ; entorhinal cortex; ; orbitofrontal cortex; ; external globus pallidus; ; pons;
	Top expressed in
	olfactory tubercle; ; hippocampus proper; ; lateral septal nucleus; ; globus pallidus; ; nucleus accumbens; ; anterior amygdaloid area; ; lobe of cerebellum; ; subiculum; ; Region I of hippocampus proper; ; prefrontal cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phosphoprotein phosphatase activity; protein dimerization activity; protein serine/threonine phosphatase activity; metal ion binding; calmodulin binding; protein binding; protein heterodimerization activity; enzyme binding; calcium-dependent protein serine/threonine phosphatase activity; hydrolase activity; cyclosporin A binding; calmodulin-dependent protein phosphatase activity;
Cellular component	membrane; plasma membrane; calcineurin complex; nucleoplasm; Z discdkac; mitochondrion; sarcolemma; nucleus; cytosol; cytoplasm; cytoplasmic side of plasma membrane; dendritic spine; slit diaphragm; cell projection; synapse; Schaffer collateral - CA1 synapse; glutamatergic synapse;
Biological process	multicellular organismal response to stress; negative regulation of insulin secretion; protein import into nucleus; transition between fast and slow fiber; negative regulation of chromatin binding; response to amphetamine; modulation of chemical synaptic transmission; positive regulation of DNA-binding transcription factor activity; response to calcium ion; Fc-epsilon receptor signaling pathway; cardiac muscle hypertrophy in response to stress; negative regulation of dendrite morphogenesis; skeletal muscle fiber development; positive regulation of cardiac muscle hypertrophy in response to stress; excitatory postsynaptic potential; T cell activation; cellular response to glucose stimulus; calcium ion transport; calcium-mediated signaling; dephosphorylation; positive regulation of transcription by RNA polymerase II; Wnt signaling pathway, calcium modulating pathway; positive regulation of cardiac muscle hypertrophy; positive regulation of gene expression; negative regulation of gene expression; negative regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of connective tissue replacement; positive regulation of endocytosis; G1/S transition of mitotic cell cycle; protein dephosphorylation; calcineurin-NFAT signaling cascade; positive regulation of calcineurin-NFAT signaling cascade; brain development; positive regulation of cell migration; skeletal muscle tissue regeneration; positive regulation of cell adhesion; calcineurin-mediated signaling; postsynaptic modulation of chemical synaptic transmission; ageing; peptidyl-serine dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	5530
	19055
	ENSG00000138814
	ENSMUSG00000028161
	Q08209
	P63328
	NM_001130692; NM_000944; NM_001130691
	NM_001293622; NM_008913
	NP_000935; NP_001124163; NP_001124164
	NP_001280551; NP_032939
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA) is a protein that in humans is encoded by the PPP3CA gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000138814 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028161 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Universal protein resource accession number Q08209 for "Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform" at UniProt.
"Entrez Gene: Protein phosphatase 3, catalytic subunit, alpha isozyme". Retrieved 2011-12-18.

Further reading

Crabtree GR (March 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. 96 (5): 611–4. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876. S2CID 8817053.
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC (April 1999). "Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD". Science. 284 (5412): 339–43. Bibcode:1999Sci...284..339W. doi:10.1126/science.284.5412.339. PMID 10195903.
Fuentes JJ, Genescà L, Kingsbury TJ, Cunningham KW, Pérez-Riba M, Estivill X, de la Luna S (July 2000). "DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways". Human Molecular Genetics. 9 (11): 1681–90. doi:10.1093/hmg/9.11.1681. PMID 10861295.
Frey N, Richardson JA, Olson EN (December 2000). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196.
Siddiq A, Miyazaki T, Takagishi Y, Kanou Y, Hayasaka S, Inouye M, Seo H, Murata Y (May 2001). "Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism". Endocrinology. 142 (5): 1752–9. doi:10.1210/endo.142.5.8156. PMID 11316738.
Graef IA, Chen F, Chen L, Kuo A, Crabtree GR (June 2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature". Cell. 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183. S2CID 5278706.
Mukerjee N, McGinnis KM, Gnegy ME, Wang KK (August 2001). "Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation". Biochemical and Biophysical Research Communications. 285 (5): 1192–9. CiteSeerX 10.1.1.414.4108. doi:10.1006/bbrc.2001.5278. PMID 11478781.
Volkel H, Scholz M, Link J, Selzle M, Werner P, Tunnemann R, Jung G, Ludolph AC, Reuter A (August 2001). "Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin". FEBS Letters. 503 (2–3): 201–5. doi:10.1016/S0014-5793(01)02730-2. PMID 11513882. S2CID 44432580.
Esau C, Boes M, Youn HD, Tatterson L, Liu JO, Chen J (November 2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". The Journal of Experimental Medicine. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671. PMID 11714752.
Frey N, Olson EN (April 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". The Journal of Biological Chemistry. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138814 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028161 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Universal protein resource accession number Q08209 for "Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform" at UniProt.

[entrez-6] "Entrez Gene: Protein phosphatase 3, catalytic subunit, alpha isozyme". Retrieved 2011-12-18.

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