POLR1A

POLR1A
Identifiers
Aliases	POLR1A, A190, RPA1, RPA194, RPO1-4, RPO14, AFDCIN, polymerase (RNA) I subunit A, RNA polymerase I subunit A, RPA190
External IDs	OMIM: 616404; MGI: 1096397; HomoloGene: 7033; GeneCards: POLR1A; OMA:POLR1A - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	86,106,155 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	71,961,919 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; tibialis anterior muscle; ; stromal cell of endometrium; ; gonad; ; testicle; ; islet of Langerhans; ; ventricular zone; ; gastrocnemius muscle; ; muscle of thigh; ; body of uterus;
	Top expressed in
	granulocyte; ; tail of embryo; ; epiblast; ; choroid plexus of fourth ventricle; ; primitive streak; ; genital tubercle; ; Epithelium of choroid plexus; ; yolk sac; ; spermatocyte; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; zinc ion binding; metal ion binding; DNA-directed 5'-3' RNA polymerase activity; protein binding; RNA polymerase I activity; chromatin binding;
Cellular component	nucleoplasm; RNA polymerase I complex; nucleus; nucleolus;
Biological process	termination of RNA polymerase I transcription; epigenetic maintenance of chromatin in transcription-competent conformation; transcription initiation from RNA polymerase I promoter; transcription, DNA-templated; negative regulation of protein localization to nucleolus; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	25885
	20019
	ENSG00000068654
	ENSMUSG00000049553
	O95602
	O35134
	NM_015425
	NM_009088
	NP_056240
	NP_033114
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000068654 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000049553 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Seither P, Coy JF, Pouska A, Grummt I (Aug 1997). "Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I". Mol Gen Genet. 255 (2): 180–6. doi:10.1007/s004380050487. PMID 9236775. S2CID 21286746.
"Entrez Gene: POLR1A polymerase (RNA) I polypeptide A, 194kDa".

Further reading

Zhu L, Perlaky L, Henning D, Valdez BC (1998). "Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family". Biochem. Mol. Biol. Int. 42 (5): 927–35. doi:10.1080/15216549700203371. PMID 9285060. S2CID 19749385.
Chen HK, Pai CY, Huang JY, Yeh NH (2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol. Cell. Biol. 19 (12): 8536–46. doi:10.1128/mcb.19.12.8536. PMC 84972. PMID 10567578.
Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
Yuan X, Zhao J, Zentgraf H, et al. (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
Dundr M, Hoffmann-Rohrer U, Hu Q, et al. (2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID 12446911. S2CID 36392120.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Percipalle P, Fomproix N, Cavellán E, et al. (2006). "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC 1479564. PMID 16514417.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000068654 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049553 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9236775-5] Seither P, Coy JF, Pouska A, Grummt I (Aug 1997). "Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I". Mol Gen Genet. 255 (2): 180–6. doi:10.1007/s004380050487. PMID 9236775. S2CID 21286746.

[entrez-6] "Entrez Gene: POLR1A polymerase (RNA) I polypeptide A, 194kDa".

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