PLEK2

PLEK2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X1G
Identifiers
Aliases	PLEK2, pleckstrin 2
External IDs	OMIM: 608007; MGI: 1351466; HomoloGene: 8447; GeneCards: PLEK2; OMA:PLEK2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,412,167 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	78,953,738 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; mucosa of transverse colon; ; right adrenal cortex; ; gingival epithelium; ; left adrenal gland; ; left adrenal cortex; ; corpus epididymis; ; rectum; ; jejunal mucosa;
	Top expressed in
	Paneth cell; ; molar; ; fetal liver hematopoietic progenitor cell; ; lumbar spinal ganglion; ; gastric mucosa; ; mucous cell of stomach; ; epithelium of stomach; ; pyloric antrum; ; duodenum; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3,5-bisphosphate binding; phosphatidylinositol-3-phosphate binding;
Cellular component	cytoplasm; plasma membrane; cell projection; lamellipodium membrane; cytoskeleton; membrane;
Biological process	intracellular signal transduction; actin cytoskeleton organization; positive regulation of cell projection organization; actin cytoskeleton reorganization; positive regulation of plasma membrane bounded cell projection assembly;
	Sources:Amigo / QuickGO
Orthologs
	26499
	27260
	ENSG00000100558
	ENSMUSG00000021118
	Q9NYT0
	Q9WV52
	NM_016445
	NM_013738
	NP_057529
	NP_038766
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin-2 is a protein that in humans is encoded by the PLEK2 gene.⁵⁶⁷ The PLEK2 gene is located on chromosome 14 in Homo sapiens and is flanked by TMEM229B to its right and ATP6V1D to its left.⁸

References

GRCh38: Ensembl release 89: ENSG00000100558 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021118 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lemmon, Mark A.; Ferguson, Kathryn M.; Abrams, Charles S. (2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Letters. 513 (1): 71–76. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883.
Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun. 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464.
"Entrez Gene: PLEK2 pleckstrin 2".
"AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011.

Further reading

Bach TL, Kerr WT, Wang Y, et al. (2007). "PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization". Blood. 109 (3): 1147–55. doi:10.1182/blood-2006-02-001339. PMC 1785144. PMID 17008542.
Inazu T, Kuroiwa A, Matsuda Y, Miyamoto K (2005). "Cloning, expression and chromosomal assignment of human pleckstrin 2". Mol. Biol. Rep. 32 (1): 35–40. doi:10.1007/s11033-004-4747-x. PMID 15865208. S2CID 8131790.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Inazu T, Yamada K, Miyamoto K (1999). "Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family". Biochem. Biophys. Res. Commun. 265 (1): 87–93. doi:10.1006/bbrc.1999.1461. PMID 10548495.
Hu MH, Bauman EM, Roll RL, et al. (1999). "Pleckstrin 2, a widely expressed paralog of pleckstrin involved in actin rearrangement". J. Biol. Chem. 274 (31): 21515–8. doi:10.1074/jbc.274.31.21515. PMID 10419454.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100558 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021118 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11911883-5] Lemmon, Mark A.; Ferguson, Kathryn M.; Abrams, Charles S. (2002). "Pleckstrin homology domains and the cytoskeleton". FEBS Letters. 513 (1): 71–76. doi:10.1016/S0014-5793(01)03243-4. PMID 11911883.

[pmid17658464-6] Hamaguchi N, Ihara S, Ohdaira T, Nagano H, Iwamatsu A, Tachikawa H, Fukui Y (Aug 2007). "Pleckstrin-2 selectively interacts with phosphatidylinositol 3-kinase lipid products and regulates actin organization and cell spreading". Biochem Biophys Res Commun. 361 (2): 270–5. doi:10.1016/j.bbrc.2007.06.132. PMID 17658464.

[entrez-7] "Entrez Gene: PLEK2 pleckstrin 2".

[AceView-8] "AceView: PLEK2 gene". AceView. National Library of Medicine. Retrieved 24 April 2011.

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