PITPNM1

PITPNM1
Identifiers
Aliases	PITPNM1, DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9, phosphatidylinositol transfer protein membrane associated 1
External IDs	OMIM: 608794; MGI: 1197524; HomoloGene: 3608; GeneCards: PITPNM1; OMA:PITPNM1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	67,506,263 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right uterine tube; ; olfactory zone of nasal mucosa; ; anterior pituitary; ; right frontal lobe; ; right hemisphere of cerebellum; ; monocyte; ; lateral nuclear group of thalamus; ; cingulate gyrus; ; anterior cingulate cortex;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding; phosphatidylinositol transfer activity; phosphatidylcholine binding; phosphatidylinositol binding; phosphatidic acid binding; phospholipid transporter activity; calcium ion binding; receptor tyrosine kinase binding; phosphatidylcholine transporter activity;
Cellular component	Golgi cisterna membrane; lipid droplet; Golgi apparatus; midbody; cleavage furrow; intracellular anatomical structure; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; cytoplasm; cytosol; cytoplasmic ribonucleoprotein granule; microtubule organizing center; cell body;
Biological process	protein transport; brain development; lipid metabolism; phototransduction; phosphatidylinositol biosynthetic process; phospholipid transport;
	Sources:Amigo / QuickGO
Orthologs
	9600
	18739
	ENSG00000110697
	ENSMUSG00000024851
	O00562
	O35954
	NM_001130848; NM_004910
	NM_001136078; NM_008851
	NP_001124320; NP_004901
	NP_032877
	Wikidata
View/Edit Human	View/Edit Mouse

Membrane-associated phosphatidylinositol transfer protein 1 is a protein that in humans is encoded by the PITPNM1 gene.⁴⁵

Function

PITPNM1 belongs to a family of proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein.[supplied by OMIM]⁵

Interactions

PITPNM1 has been shown to interact with PTK2B.⁶

References

GRCh38: Ensembl release 89: ENSG00000110697 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (1997). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295.
"Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".
Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. 19 (3) (published March 1999): 2278–88. doi:10.1128/mcb.19.3.2278. ISSN 0270-7306. PMC 84020. PMID 10022914. Wikidata Q22008764.

Further reading

Vihtelic TS, Hyde DR, O'Tousa JE (1991). "Isolation and characterization of the Drosophila retinal degeneration B (rdgB) gene". Genetics. 127 (4): 761–8. doi:10.1093/genetics/127.4.761. PMC 1204403. PMID 1903119.
Aikawa Y, Hara H, Watanabe T (1997). "Molecular cloning and characterization of mammalian homologues of the Drosophila retinal degeneration B gene". Biochem. Biophys. Res. Commun. 236 (3): 559–64. doi:10.1006/bbrc.1997.7009. PMID 9245688.
Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S (2002). "Nir2, a novel regulator of cell morphogenesis". Mol. Cell. Biol. 22 (8): 2650–62. doi:10.1128/MCB.22.8.2650-2662.2002. PMC 133726. PMID 11909959.
Litvak V, Tian D, Carmon S, Lev S (2002). "Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis". Mol. Cell. Biol. 22 (14): 5064–75. doi:10.1128/MCB.22.14.5064-5075.2002. PMC 139767. PMID 12077336.
Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S (2002). "Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain". Curr. Biol. 12 (17): 1513–8. Bibcode:2002CBio...12.1513L. doi:10.1016/S0960-9822(02)01107-7. PMID 12225667. S2CID 5639384.
Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S (2004). "Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion". Mol. Cell. 14 (3): 319–30. doi:10.1016/S1097-2765(04)00214-X. PMID 15125835.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Amarilio R, Ramachandran S, Sabanay H, Lev S (2005). "Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction". J. Biol. Chem. 280 (7): 5934–44. doi:10.1074/jbc.M409566200. PMID 15545272.
Ocaka L, Spalluto C, Wilson DI, Hunt DM, Halford S (2005). "Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane-associated (PITPNM) 1, 2 and 3". Cytogenet. Genome Res. 108 (4): 293–302. doi:10.1159/000081519. PMID 15627748. S2CID 20792950.
Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S (2005). "Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function". Nat. Cell Biol. 7 (3): 225–34. doi:10.1038/ncb1221. PMID 15723057. S2CID 5881790.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Burgis NE, Cunningham RP (2007). "Substrate specificity of RdgB protein, a deoxyribonucleoside triphosphate pyrophosphohydrolase". J. Biol. Chem. 282 (6): 3531–8. doi:10.1074/jbc.M608708200. PMID 17090528.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110697 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9680295-4] Rubboli F, Bulfone A, Bogni S, Marchitiello A, Zollo M, Borsani G, Ballabio A, Banfi S (1997). "A mammalian homologue of the Drosophila retinal degeneration B gene: implications for the evolution of phototransduction mechanisms". Genes Funct. 1 (3): 205–13. doi:10.1046/j.1365-4624.1997.00015.x. PMID 9680295.

[entrez-5] "Entrez Gene: PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1".

[pmid10022914-6] Lev S, Hernandez J, Martinez R, Chen A, Plowman G, Schlessinger J (Mar 1999). "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein". Mol. Cell. Biol. 19 (3) (published March 1999): 2278–88. doi:10.1128/mcb.19.3.2278. ISSN 0270-7306. PMC 84020. PMID 10022914. Wikidata Q22008764.

1

2

3

4

5

6