PIK3R5

PIK3R5
Identifiers
Aliases	PIK3R5, F730038I15Rik, FOAP-2, P101-PI3K, p101, phosphoinositide-3-kinase regulatory subunit 5
External IDs	OMIM: 611317; MGI: 2443588; HomoloGene: 8627; GeneCards: PIK3R5; OMA:PIK3R5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	8,965,712 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	68,388,675 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; spleen; ; bone marrow cell; ; upper lobe of left lung; ; lymph node; ; right lung; ; appendix; ; gallbladder;
	Top expressed in
	granulocyte; ; thymus; ; blood; ; mesenteric lymph nodes; ; stroma of bone marrow; ; spleen; ; outer nuclear layer; ; otic vesicle; ; subcutaneous adipose tissue; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G-protein beta/gamma-subunit complex binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; plasma membrane; phosphatidylinositol 3-kinase complex, class IB; membrane; nucleus; phosphatidylinositol 3-kinase complex; microtubule organizing center; cytosol;
Biological process	platelet activation; positive regulation of protein kinase B signaling; regulation of phosphatidylinositol 3-kinase activity; positive regulation of MAP kinase activity; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphate biosynthetic process; G protein-coupled receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase signaling; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	23533
	320207
	ENSG00000141506
	ENSMUSG00000020901
	Q8WYR1
	Q5SW28
NM_001142633; NM_001251851; NM_001251852; NM_001251853; NM_001251855;
	NM_014308; NM_001388396; NM_001388397; NM_001388398; NM_001388399; NM_001388400
	NM_177320
NP_001136105; NP_001238780; NP_001238781; NP_001238782; NP_001238784;
	NP_055123
	NP_796294.2; NP_796294
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 5 is an enzyme that in humans is encoded by the PIK3R5 gene.⁵⁶

Interactions

PIK3R5 has been shown to interact with PIK3CG.⁵

References

GRCh38: Ensembl release 89: ENSG00000141506 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020901 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Brock C, Schaefer M, Reusch HP, et al. (Jan 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.
"Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101".

Further reading

Johnson C, Marriott SJ, Levy LS (2007). "Overexpression of p101 activates PI3Kgamma signaling in T cells and contributes to cell survival". Oncogene. 26 (49): 7049–57. doi:10.1038/sj.onc.1210504. PMID 17486067.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Suire S, Coadwell J, Ferguson GJ, et al. (2005). "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma". Curr. Biol. 15 (6): 566–70. Bibcode:2005CBio...15..566S. doi:10.1016/j.cub.2005.02.020. PMID 15797027. S2CID 12255918.
Voigt P, Brock C, Nürnberg B, et al. (2005). "Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma". J. Biol. Chem. 280 (6): 5121–7. doi:10.1074/jbc.M413104200. PMID 15611065.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Metjian A, Roll RL, Ma AD, et al. (1999). "Agonists cause nuclear translocation of phosphatidylinositol 3-kinase gamma. A Gbetagamma-dependent pathway that requires the p110gamma amino terminus". J. Biol. Chem. 274 (39): 27943–7. doi:10.1074/jbc.274.39.27943. PMID 10488142.
Krugmann S, Hawkins PT, Pryer N, et al. (1999). "Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits". J. Biol. Chem. 274 (24): 17152–8. doi:10.1074/jbc.274.24.17152. PMID 10358071.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141506 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020901 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12507995-5] Brock C, Schaefer M, Reusch HP, et al. (Jan 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J Cell Biol. 160 (1): 89–99. doi:10.1083/jcb.200210115. PMC 2172741. PMID 12507995.

[entrez-6] "Entrez Gene: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5, p101".

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