Article · Wikipedia archive · Last revised Jul 29, 2026

Pheneturide

Pheneturide, also known as phenylethylacetylurea, is an anticonvulsant of the ureide class. Conceptually, it can be formed in the body as a metabolic degradation product from phenobarbital. It is considered to be obsolete and is now seldom used. It is marketed in Europe, including in Poland, Spain and the United Kingdom. Pheneturide has a similar profile of anticonvulsant activity and toxicity relative to phenacemide. As such, it is only used in cases of severe epilepsy when other, less-toxic drugs have failed. Pheneturide inhibits the metabolism and thus increases the levels of other anticonvulsants, such as phenytoin.

Last revised
Jul 29, 2026
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Pheneturide
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • (RS)-N-Carbamoyl-2-phenyl-butanamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.001.817
Chemical and physical data
FormulaC11H14N2O2
Molar mass206.245 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • O=C(N)NC(=O)C(c1ccccc1)CC
  • InChI=1S/C11H14N2O2/c1-2-9(10(14)13-11(12)15)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3,(H3,12,13,14,15) checkY
  • Key:AJOQSQHYDOFIOX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Pheneturide (INN, BAN) (brand names Benuride, Deturid, Pheneturid, Septotence, Trinuride),1 also known as phenylethylacetylurea (or ethylphenacemide), is an anticonvulsant of the ureide class.23 Conceptually, it can be formed in the body as a metabolic degradation product from phenobarbital. It is considered to be obsolete4 and is now seldom used.5 It is marketed in Europe, including in Poland, Spain and the United Kingdom.6 Pheneturide has a similar profile of anticonvulsant activity and toxicity relative to phenacemide.78 As such, it is only used in cases of severe epilepsy when other, less-toxic drugs have failed.8 Pheneturide inhibits the metabolism and thus increases the levels of other anticonvulsants, such as phenytoin.56

See also

See also

References

References

  1. Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 998–. ISBN 978-3-7692-2114-5.
  2. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 959–. ISBN 978-1-4757-2085-3.
  3. Byrne B, Rothchild R (1999). "1H NMR studies of drugs with achiral and chiral lanthanide shift reagents: applications to the anticonvulsant pheneturide". Chirality. 11 (7): 529–35. doi:10.1002/(SICI)1520-636X(1999)11:7<529::AID-CHIR3>3.0.CO;2-K. PMID 10423278.
  4. Levy RH (2002). Antiepileptic Drugs. Lippincott Williams & Wilkins. pp. 210–. ISBN 978-0-7817-2321-3.
  5. Denham MJ (6 December 2012). The Treatment of Medical Problems in the Elderly. Springer Science & Business Media. pp. 335–. ISBN 978-94-011-6223-4.
  6. Vida J (19 July 2013). Anticonvulsants. Elsevier. pp. 4, 42. ISBN 978-0-323-14395-0.
  7. deStevens G, Zingel V, Leschke C, Hoeprich PD, Schultz RM, Mehrotra PK, Batra S, Bhaduri AP, Saxena AK, Saxena M, eds. (11 November 2013). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques. Basel: Birkhäuser. pp. 217–. ISBN 978-3-0348-7161-7. Retrieved 3 September 2016.
  8. Lancaster R (22 October 2013). Pharmacology in Clinical Practice. Elsevier. pp. 222–. ISBN 978-1-4831-9294-9.