PHACTR3

PHACTR3
Identifiers
Aliases	PHACTR3, C20orf101, H17739, PPP1R123, SCAPIN1, SCAPININ, phosphatase and actin regulator 3
External IDs	OMIM: 608725; MGI: 1921439; GeneCards: PHACTR3
Gene location (Human)
Chr.	Chromosome 20 (human)
End	59,847,711 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	177,980,285 bp
RNA expression pattern
	Top expressed in
	amygdala; ; internal globus pallidus; ; C1 segment; ; substantia nigra; ; corpus callosum; ; cingulate gyrus; ; anterior cingulate cortex; ; right frontal lobe; ; Brodmann area 9; ; hippocampus proper;
	Top expressed in
	piriform cortex; ; olfactory tubercle; ; superior frontal gyrus; ; cingulate gyrus; ; globus pallidus; ; superior cervical ganglion; ; temporal lobe; ; visual cortex; ; primary motor cortex; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein phosphatase inhibitor activity; protein phosphatase 1 binding; actin binding; protein phosphatase regulator activity;
Cellular component	nuclear matrix; nucleus; nucleoplasm;
Biological process	negative regulation of phosphoprotein phosphatase activity; regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	116154
	74189
	ENSG00000087495
	ENSMUSG00000027525
	Q96KR7
	Q8BYK5
NM_001199505; NM_001199506; NM_001281507; NM_080672; NM_183244;
	NM_183246
	NM_001007154; NM_001177789; NM_001177790; NM_001177791; NM_028806
NP_001186434; NP_001186435; NP_001268436; NP_542403; NP_899067;
	NP_899069
	NP_001007155; NP_001171260; NP_001171261; NP_001171262; NP_083082
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.⁵⁶

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.⁶

Interactions

PHACTR3 has been shown to interact with PPP1CA.⁷

References

GRCh38: Ensembl release 89: ENSG00000087495 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027525 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. Bibcode:2004PNAS..101.7187A. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.
"Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

Further reading

Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human". Cytogenet. Genome Res. 115 (1): 23–9. doi:10.1159/000094797. PMID 16974080. S2CID 38349132.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087495 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027525 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15107502-5] Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A. 101 (18): 7187–92. Bibcode:2004PNAS..101.7187A. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.

[entrez-6] "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".

[pmid12925532-7] Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

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