Article · Wikipedia archive · Last revised Aug 7, 2026

PHA-57378

PHA-57378 is a drug related to the ibogalogs which acts as an agonist at serotonin 5-HT2 receptors, having a binding affinity of 4.1 nM at the 5-HT2A subtype and 4.3 nM at 5-HT2C. It has anxiolytic effects in animal studies.

Last revised
Aug 7, 2026
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≈ 1 min
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PHA-57378
Identifiers
  • 2,7,8,9,10,11-hexahydro-1H-azepino[4,5-b][1,4]oxazino[2,3,4-hi]indole
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H16N2O
Molar mass228.295 g·mol−1
3D model (JSmol)
  • C1(OCC2)=C(N2C3=C4CCNCC3)C4=CC=C1
  • InChI=1S/C14H16N2O/c1-2-11-10-4-6-15-7-5-12(10)16-8-9-17-13(3-1)14(11)16/h1-3,15H,4-9H2
  • Key:KMVAXNRPZRSLSY-UHFFFAOYSA-N

PHA-57378 is a drug related to the ibogalogs which acts as an agonist at serotonin 5-HT2 receptors,1 having a binding affinity of 4.1 nM at the 5-HT2A subtype and 4.3 nM at 5-HT2C. It has anxiolytic effects in animal studies.2

See also

See also

References

References

  1. WO application 2000064899, Hester JB, Rogers BN, Jacobsen EJ, Ennis MD, Acker BA, Van der Velde SL, Frank KE, "Tetracyclic Azepinoindole Compounds as 5-HT Receptor Ligands", published 2 November 2000, assigned to Pharmacia Upjohn Company 
  2. Ennis MD, Hoffman RL, Ghazal NB, Olson RM, Knauer CS, Chio CL, et al. (July 2003). "2,3,4,5-tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT(2C) agonists". Bioorganic & Medicinal Chemistry Letters. 13 (14): 2369–72. doi:10.1016/S0960-894X(03)00403-7. PMID 12824036.