Peroxiredoxin 1

PRDX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RII, 3HY2, 4XCS
Identifiers
Aliases	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2, Peroxiredoxin 1
External IDs	OMIM: 176763; MGI: 99523; HomoloGene: 99789; GeneCards: PRDX1; OMA:PRDX1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)1 Band 1p34.1 Start 45,510,914 bp1 End 45,542,732 bp1
Gene location (Mouse) Chr. Chromosome 4 (mouse)2 Band 4 D1|4 53.28 cM Start 116,542,741 bp2 End 116,558,019 bp2
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland nasal epithelium olfactory zone of nasal mucosa palpebral conjunctiva C1 segment mucosa of esophagus ganglionic eminence gums gingival epithelium Top expressed in vas deferens primitive streak endothelial cell of lymphatic vessel right kidney Gonadal ridge efferent ductule lobe of prostate stroma of bone marrow iris epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antioxidant activity protein binding peroxiredoxin activity identical protein binding oxidoreductase activity thioredoxin peroxidase activity peroxidase activity RNA binding cadherin binding Cellular component cytoplasm cytosol melanosome myelin sheath mitochondrion extracellular exosome nucleus extracellular matrix extracellular space Biological process skeletal system development removal of superoxide radicals response to oxidative stress retina homeostasis erythrocyte homeostasis hydrogen peroxide catabolic process cell population proliferation regulation of stress-activated MAPK cascade natural killer cell mediated cytotoxicity cell redox homeostasis natural killer cell activation response to reactive oxygen species cellular response to oxidative stress regulation of NIK/NF-kappaB signaling leukocyte activation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5052 18477 Ensembl ENSG00000117450 ENSMUSG00000028691 UniProt Q06830 P35700 RefSeq (mRNA) NM_181697 NM_001202431 NM_002574 NM_181696 NM_011034 RefSeq (protein) NP_001189360 NP_002565 NP_859047 NP_859048 NP_035164 Location (UCSC) Chr 1: 45.51 – 45.54 Mb Chr 4: 116.54 – 116.56 Mb PubMed search 3 4
Wikidata
View/Edit Human View/Edit Mouse

Peroxiredoxin-1 is a protein that in humans is encoded by the PRDX1 gene.⁵⁶

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides.⁷ The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene.⁶

Peroxiredoxin 1 has been shown to interact with PRDX4.⁸ A chemoproteomic approach has revealed that peroxiredoxin 1 is the main target of theonellasterone.⁹

As enzymes that combat oxidative stress, peroxiredoxins play an important role in health and disease.¹⁰ Peroxiredoxin 1 and peroxiredoxin 2 have been shown to be released by some cells when stimulated by LPS or TNF-alpha.¹¹ The released peroxiredoxin can then act to produce inflammatory cytokines.¹¹ The levels of peroxiredoxin 1 are elevated in pancreatic cancer and it can potentially act as a marker for the diagnosis and prognosis of this disease.¹² In some types of cancer, peroxiredoxin 1 has been determined to act as a tumor suppressor and other studies show that peroxiredoxin 1 is overexpressed in certain human cancers.¹³ A recent study has found that peroxiredoxin 1 may play a role in tumorigenesis by regulating the mTOR/p70S6K pathway in esophageal squamous cell carcinoma.¹³ The expression patterns of peroxiredoxin 1 along with peroxiredoxin 4 are involved in human lung cancer malignancy.¹⁴ It has also been shown that peroxiredoxin 1 may be an important player in the pathogenesis of acute respiratory distress syndrome because of its role in promoting inflammation.¹⁵