PCDH7

PCDH7
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2YST
Identifiers
Aliases	PCDH7, BH-Pcdh, BHPCDH, PPP1R120, protocadherin 7
External IDs	OMIM: 602988; MGI: 1860487; HomoloGene: 36101; GeneCards: PCDH7; OMA:PCDH7 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	31,146,805 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	58,290,572 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; urethra; ; saphenous vein; ; corpus epididymis; ; seminal vesicula; ; pons; ; entorhinal cortex; ; postcentral gyrus;
	Top expressed in
	ascending aorta; ; arcuate nucleus; ; anterior amygdaloid area; ; ventromedial nucleus; ; subiculum; ; median eminence; ; paraventricular nucleus of hypothalamus; ; lateral geniculate nucleus; ; aortic valve; ; medial geniculate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; platelet alpha granule membrane;
Biological process	cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; platelet degranulation;
	Sources:Amigo / QuickGO
Orthologs
	5099
	54216
	ENSG00000169851
	ENSMUSG00000029108
	O60245
	n/a
	NM_001173523; NM_002589; NM_032456; NM_032457
	NM_001122758; NM_018764; NM_001310606; NM_001310608
	NP_001166994; NP_002580; NP_115832; NP_115833
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.⁵⁶

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell–cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails.⁶

References

GRCh38: Ensembl release 89: ENSG00000169851 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029108 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics. 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID 9615233.
"Entrez Gene: PCDH7 protocadherin 7".

Further reading

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
Yoshida K, Watanabe M, Kato H, et al. (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain". FEBS Lett. 460 (1): 93–8. doi:10.1016/S0014-5793(99)01309-5. PMID 10571067. S2CID 24377126.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169851 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029108 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9615233-5] Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics. 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID 9615233.

[entrez-6] "Entrez Gene: PCDH7 protocadherin 7".

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