PCDH17

PCDH17
Identifiers
Aliases	PCDH17, PCDH68, PCH68, protocadherin 17
External IDs	OMIM: 611760; MGI: 2684924; HomoloGene: 8700; GeneCards: PCDH17; OMA:PCDH17 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	57,729,311 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	84,776,442 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; visceral pleura; ; sperm; ; Brodmann area 23; ; entorhinal cortex; ; lower lobe of lung; ; pars reticulata; ; superior vestibular nucleus; ; germinal epithelium; ; ventral tegmental area;
	Top expressed in
	lateral hypothalamus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; anterior amygdaloid area; ; mammillary body; ; lateral septal nucleus; ; paraventricular nucleus of hypothalamus; ; ventral tegmental area; ; arcuate nucleus; ; supraoptic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane;
Biological process	presynaptic active zone assembly; adult behavior; regulation of synaptic vesicle clustering; negative regulation of synaptic transmission; homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell signaling; synapse assembly; synaptic membrane adhesion;
	Sources:Amigo / QuickGO
Orthologs
	27253
	219228
	ENSG00000118946
	ENSMUSG00000035566
	O14917
	n/a
	NM_001040429; NM_014459
	NM_001013753
	NP_001035519
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene.⁵⁶

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.⁶ PCDH17 promoter methylation is found to be closely associated with bladder cancer malignancy ⁷

References

GRCh38: Ensembl release 89: ENSG00000118946 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035566 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
"Entrez Gene: PCDH17 protocadherin 17".
Wang XB (Apr 2014). "Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma". J Int Med Res. 42 (2): 292–9. doi:10.1177/0300060513504364. PMID 24567353. S2CID 38799502.

Further reading

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752. S2CID 44844497.
Suzuki ST (2000). "Recent progress in protocadherin research". Exp. Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. Bibcode:2000PNAS...97.3124W. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. S2CID 21903526.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118946 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035566 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10835267-5] Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.

[entrez-6] "Entrez Gene: PCDH17 protocadherin 17".

[pmid_=_24567353-7] Wang XB (Apr 2014). "Protocadherin 17 promoter methylation in tumour tissue from patients with bladder transitional cell carcinoma". J Int Med Res. 42 (2): 292–9. doi:10.1177/0300060513504364. PMID 24567353. S2CID 38799502.

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