Pappalysin-2

PAPPA2
Identifiers
Aliases	PAPPA2, PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin 2, SSDA
External IDs	MGI: 3051647; HomoloGene: 10661; GeneCards: PAPPA2; OMA:PAPPA2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	176,845,601 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	158,808,060 bp
RNA expression pattern
	Top expressed in
	decidua; ; islet of Langerhans; ; cartilage tissue; ; ventricular zone; ; buccal mucosa cell; ; testicle; ; ganglionic eminence; ; human kidney; ; pancreatic ductal cell; ; stromal cell of endometrium;
	Top expressed in
	calvaria; ; islet of Langerhans; ; lumbar spinal ganglion; ; pituitary gland; ; pontine nuclei; ; trigeminal ganglion; ; dermis; ; lobe of prostate; ; efferent ductule; ; condyle;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity;
Cellular component	extracellular region; extracellular exosome; intracellular anatomical structure; cytosol; apical plasma membrane;
Biological process	bone morphogenesis; regulation of cell growth; proteolysis; response to salt stress;
	Sources:Amigo / QuickGO
Orthologs
	60676
	23850
	ENSG00000116183
	ENSMUSG00000073530
	Q9BXP8
	n/a
	NM_020318; NM_021936
	NM_001085376
	NP_064714; NP_068755
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.⁵⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000116183 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000073530 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (Nov 2000). "Pregnancy-associated plasma protein-E (PAPP-E)". Biochim Biophys Acta. 1493 (3): 356–62. doi:10.1016/s0167-4781(00)00195-0. PMID 11018262.
Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (Jun 2001). "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem. 276 (24): 21849–53. doi:10.1074/jbc.M102191200. PMID 11264294.
"Entrez Gene: PAPPA2 pappalysin 2".

Further reading

Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant". Placenta. 22 (8–9): 681–7. doi:10.1053/plac.2001.0709. PMID 11597188.
Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.