Article · Wikipedia archive · Last revised Jul 17, 2026

P87PIKAP

Within molecular and cell biology, p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils. It is also referred to as p84 and p87. Some studies have found P87PIKAP to have a role in carcinogenesis.

Last revised
Jul 17, 2026
Read time
≈ 1 min
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193 w
Citations
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Wikipedia ↗
Phosphoinositide-3-kinase adapter protein of 87 kDa
Identifiers
Symbolp87PIKAP
Alt. symbolsp84,PIK3R6
NCBI gene146850
HGNC27101
OMIM611462
UniProtQ5UE93
Other data
LocusChr. 17 p13.1
Search for
StructuresSwiss-model
DomainsInterPro

Within molecular and cell biology, p87PIKAP is a regulatory subunit of the type IB Phosphoinositide 3-Kinase p110γ that is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.1 It is also referred to as p84 and p87.2 Some studies have found P87PIKAP to have a role in carcinogenesis.3

References

References

  1. Voigt P, Dorner MB, Schaefer M (2006). "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B". The Journal of Biological Chemistry. 281 (15): 9977–86. doi:10.1074/jbc.M512502200. PMID 16476736.
  2. Kurig B, Shymanets A, Bohnacker T, Prajwal, Brock C, Ahmadian MR, et al. (2009). "Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma". Proceedings of the National Academy of Sciences of the United States of America. 106 (48): 20312–7. Bibcode:2009PNAS..10620312K. doi:10.1073/pnas.0905506106. PMC 2787109. PMID 19906996.
  3. Brazzatti, JA; et al. (2012). "Differential roles for the p101 and p84 regulatory subunits of PI3Kc in tumor growth and metastasis" (PDF). Oncogene. 31 (18): 2350–2361. doi:10.1038/onc.2011.414. PMID 21996737. S2CID 24708435.
The context of the function of p87. source ↗