OXR1

OXR1
Identifiers
Aliases	OXR1, TLDC3, Nbla00307, oxidation resistance 1, CHEGDD
External IDs	OMIM: 605609; MGI: 2179326; HomoloGene: 24993; GeneCards: OXR1; OMA:OXR1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	106,752,694 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	41,724,444 bp
RNA expression pattern
	Top expressed in
	pons; ; Achilles tendon; ; lateral nuclear group of thalamus; ; trigeminal ganglion; ; sperm; ; spinal ganglia; ; seminal vesicula; ; Brodmann area 23; ; corpus epididymis; ; prefrontal cortex;
	Top expressed in
	medial dorsal nucleus; ; parotid gland; ; subiculum; ; pontine nuclei; ; primary motor cortex; ; habenula; ; medial geniculate nucleus; ; lobe of cerebellum; ; cerebellar vermis; ; inferior colliculi;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; protein binding; molecular function;
Cellular component	nucleolus; mitochondrion; cellular component; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	negative regulation of neuron apoptotic process; response to oxidative stress; cellular response to hydroperoxide; adult walking behavior; neuron apoptotic process; negative regulation of cellular response to oxidative stress; negative regulation of peptidyl-cysteine S-nitrosylation; negative regulation of oxidative stress-induced neuron death;
	Sources:Amigo / QuickGO
Orthologs
	55074
	170719
	ENSG00000164830
	ENSMUSG00000022307
	Q8N573
	Q4KMM3
NM_001198532; NM_001198533; NM_001198534; NM_001198535; NM_018002;
	NM_181354
NM_001130163; NM_001130164; NM_001130165; NM_001130166; NM_130885;
	NM_001358976; NM_001358977; NM_001358978
NP_001185461; NP_001185462; NP_001185463; NP_001185464; NP_060472;
	NP_851999
NP_001123635; NP_001123636; NP_001123637; NP_001123638; NP_570955;
	NP_001345905; NP_001345906; NP_001345907
	Wikidata
View/Edit Human	View/Edit Mouse

Oxidation resistance protein 1 is a protein that in humans is encoded by the OXR1 gene.⁵⁶ Loss of OXR1 function causes decline of the retromer complex.⁷

References

GRCh38: Ensembl release 89: ENSG00000164830 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022307 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Volkert MR, Elliott NA, Housman DE (Jan 2001). "Functional genomics reveals a family of eukaryotic oxidation protection genes". Proc Natl Acad Sci U S A. 97 (26): 14530–5. doi:10.1073/pnas.260495897. PMC 18953. PMID 11114193.
"Entrez Gene: OXR1 oxidation resistance 1".
Wilson KA, Bar S, et al. (Jan 2024). "OXR1 maintains the retromer to delay brain aging under dietary restriction". Nature Communications. 15 (1): 467. Bibcode:2024NatCo..15..467W. doi:10.1038/s41467-023-44343-3. PMC 10784588. PMID 38212606.

Further reading

Ohira M, Morohashi A, Nakamura Y, et al. (2003). "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
Durand M, Kolpak A, Farrell T, et al. (2007). "The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins". BMC Cell Biol. 8: 13. doi:10.1186/1471-2121-8-13. PMC 1847813. PMID 17391516.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Elliott NA, Volkert MR (2004). "Stress Induction and Mitochondrial Localization of Oxr1 Proteins in Yeast and Humans". Mol. Cell. Biol. 24 (8): 3180–7. doi:10.1128/MCB.24.8.3180-3187.2004. PMC 381681. PMID 15060142.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164830 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022307 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11114193-5] Volkert MR, Elliott NA, Housman DE (Jan 2001). "Functional genomics reveals a family of eukaryotic oxidation protection genes". Proc Natl Acad Sci U S A. 97 (26): 14530–5. doi:10.1073/pnas.260495897. PMC 18953. PMID 11114193.

[entrez-6] "Entrez Gene: OXR1 oxidation resistance 1".

[pmid"38212606"-7] Wilson KA, Bar S, et al. (Jan 2024). "OXR1 maintains the retromer to delay brain aging under dietary restriction". Nature Communications. 15 (1): 467. Bibcode:2024NatCo..15..467W. doi:10.1038/s41467-023-44343-3. PMC 10784588. PMID 38212606.

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