OXA1L

OXA1L
Identifiers
Aliases	OXA1L, OXA1, mitochondrial inner membrane protein, OXA1L mitochondrial inner membrane protein
External IDs	OMIM: 601066; MGI: 1916339; GeneCards: OXA1L
Gene location (Human)
Chr.	Chromosome 14 (human)
End	22,773,042 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	54,607,130 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; body of pancreas; ; thoracic diaphragm; ; gastrocnemius muscle; ; apex of heart; ; triceps brachii muscle; ; left ventricle; ; body of stomach; ; right adrenal cortex; ; rectum;
	Top expressed in
	muscle of thigh; ; yolk sac; ; genital tubercle; ; ventricular zone; ; epiblast; ; tail of embryo; ; lip; ; right kidney; ; dentate gyrus of hippocampal formation granule cell; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	mitochondrial ribosome binding; protein binding; protein homodimerization activity; membrane insertase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; integral component of mitochondrial membrane; mitochondrial membranes; mitochondrion; membrane; mitochondrial respirasome; protein-containing complex; mitochondrial matrix; integral component of mitochondrial inner membrane;
Biological process	negative regulation of ATP-dependent activity; aerobic dissimilation; mitochondrial proton-transporting ATP synthase complex assembly; protein tetramerization; negative regulation of oxidoreductase activity; mitochondrial respiratory chain complex I assembly; protein-containing complex assembly; protein transport; mitochondrial translational elongation; mitochondrial translational termination; protein insertion into mitochondrial inner membrane from matrix; mitochondrial cytochrome c oxidase assembly; protein insertion into membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	5018
	69089
	ENSG00000155463
	ENSMUSG00000000959
	Q15070
	Q8BGA9
	NM_005015
	NM_026936
	NP_005006
	NP_081212
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2.⁵ The C-terminus of this protein interacts with mitochondrial ribosomes and helps insert both mitochondrial and nuclear produced proteins into the inner membrane of the mitochondria.⁶⁷

References

GRCh38: Ensembl release 89: ENSG00000155463 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000959 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Molina-Gomes D, Bonnefoy N, Nguyen VC, Viegas-Péquignot E, Rötig A, Dujardin G (1995). "The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome". Genomics. 30 (2): 396–8. PMID 8586451.
Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL (2010). "Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes". The Journal of Biological Chemistry. 285 (36): 28353–62. doi:10.1074/jbc.M110.148262. PMC 2934699. PMID 20601428.
Haque ME, Spremulli LL, Fecko CJ (2010). "Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L". The Journal of Biological Chemistry. 285 (45): 34991–8. doi:10.1074/jbc.M110.163808. PMC 2966113. PMID 20739282.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155463 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000959 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8586451-5] Molina-Gomes D, Bonnefoy N, Nguyen VC, Viegas-Péquignot E, Rötig A, Dujardin G (1995). "The OXA1L gene that controls cytochrome oxidase assembly maps to the 14q11.2 region of the human genome". Genomics. 30 (2): 396–8. PMID 8586451.

[Haque_2010a-6] Haque ME, Elmore KB, Tripathy A, Koc H, Koc EC, Spremulli LL (2010). "Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes". The Journal of Biological Chemistry. 285 (36): 28353–62. doi:10.1074/jbc.M110.148262. PMC 2934699. PMID 20601428.

[Haque_2010b-7] Haque ME, Spremulli LL, Fecko CJ (2010). "Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L". The Journal of Biological Chemistry. 285 (45): 34991–8. doi:10.1074/jbc.M110.163808. PMC 2966113. PMID 20739282.

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