Article · Wikipedia archive · Last revised Jul 17, 2026

Opioid modulator

An opioid modulator is a drug which has mixed agonist and antagonist actions at different opioid receptors and thus cannot clearly be described as either an opioid agonist or antagonist. An example of an opioid modulator is buprenorphine, which is a partial agonist of the μ-opioid receptor and an antagonist of the κ-opioid receptor.

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Jul 17, 2026

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An opioid modulator (or opioid receptor modulator) is a drug which has mixed agonist and antagonist actions at different opioid receptors and thus cannot clearly be described as either an opioid agonist or antagonist. An example of an opioid modulator is buprenorphine, which is a partial agonist of the μ-opioid receptor and an antagonist of the κ-opioid receptor.¹

See also

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References

References

Hillemacher T, Heberlein A, Muschler MA, Bleich S, Frieling H (August 2011). "Opioid modulators for alcohol dependence". Expert Opin Investig Drugs. 20 (8): 1073–86. doi:10.1517/13543784.2011.592139. PMID 21651459. S2CID 43338618.