Olfactomedin 3

OLFM3
Identifiers
Aliases	OLFM3, NOE3, NOELIN3, OPTIMEDIN, olfactomedin 3
External IDs	OMIM: 607567; MGI: 2387329; HomoloGene: 17103; GeneCards: OLFM3; OMA:OLFM3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	101,996,926 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	114,919,371 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; superior frontal gyrus; ; Brodmann area 46; ; prefrontal cortex; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; lateral nuclear group of thalamus; ; postcentral gyrus;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; habenula; ; olfactory tubercle; ; substantia nigra; ; medial geniculate nucleus; ; mammillary body; ; lateral geniculate nucleus; ; paraventricular nucleus of hypothalamus; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	extracellular region; cell junction; Golgi apparatus; AMPA glutamate receptor complex; synapse; extracellular space;
Biological process	eye photoreceptor cell development;
	Sources:Amigo / QuickGO
Orthologs
	118427
	229759
	ENSG00000118733
	ENSMUSG00000027965
	Q96PB7
	P63056
	NM_001288821; NM_001288823; NM_058170
	NM_001286750; NM_153157; NM_153458
	NP_001275750; NP_001275752; NP_477518
	NP_001273679; NP_694797; NP_703188
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactomedin 3, also known as noelin 3 or optimedin, is a protein that in humans is encoded by the OLFM3 gene.⁵⁶⁷

Interactions

OLFM3 has been shown to interact with MYOC.⁵

References

GRCh38: Ensembl release 89: ENSG00000118733 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027965 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Torrado M, Trivedi R, Zinovieva R, Karavanova I, Tomarev SI (May 2002). "Optimedin: a novel olfactomedin-related protein that interacts with myocilin". Hum Mol Genet. 11 (11): 1291–301. doi:10.1093/hmg/11.11.1291. PMID 12019210.
Grinchuk O, Kozmik Z, Wu X, Tomarev S (Oct 2005). "The Optimedin gene is a downstream target of Pax6". J Biol Chem. 280 (42): 35228–37. doi:10.1074/jbc.M506195200. PMID 16115881.
"Entrez Gene: OLFM3 olfactomedin 3".

Further reading

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000118733 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027965 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12019210-5] Torrado M, Trivedi R, Zinovieva R, Karavanova I, Tomarev SI (May 2002). "Optimedin: a novel olfactomedin-related protein that interacts with myocilin". Hum Mol Genet. 11 (11): 1291–301. doi:10.1093/hmg/11.11.1291. PMID 12019210.

[pmid16115881-6] Grinchuk O, Kozmik Z, Wu X, Tomarev S (Oct 2005). "The Optimedin gene is a downstream target of Pax6". J Biol Chem. 280 (42): 35228–37. doi:10.1074/jbc.M506195200. PMID 16115881.

[entrez-7] "Entrez Gene: OLFM3 olfactomedin 3".

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