Article · Wikipedia archive · Last revised Aug 7, 2026

NUFIP2

Nuclear fragile X mental retardation-interacting protein 2 is a protein that in humans is encoded by the NUFIP2 gene.

Last revised
Aug 7, 2026
Read time
≈ 3 min
Length
626 w
Citations
13
Source
NUFIP2
Identifiers
AliasesNUFIP2, 182-FIP, 82-FIP, FIP-82, PIG1, FMR1 interacting protein 2, nuclear FMR1 interacting protein 2, NUFP2
External IDsOMIM: 609356; MGI: 1915814; HomoloGene: 10808; GeneCards: NUFIP2; OMA:NUFIP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020772

NM_001024205

RefSeq (protein)

NP_065823
NP_065823.1

NP_001019376

Location (UCSC)Chr 17: 29.26 – 29.29 MbChr 11: 77.58 – 77.63 Mb
PubMed search34
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear fragile X mental retardation-interacting protein 2 is a protein that in humans is encoded by the NUFIP2 gene.567

Interactions

NUFIP2 has been shown to interact with FMR1 and Roquin-1.85

References

References

  1. GRCh38: Ensembl release 89: ENSG00000108256Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037857Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bardoni B, Castets M, Huot ME, Schenck A, Adinolfi S, Corbin F, Pastore A, Khandjian EW, Mandel JL (Jul 2003). "82-FIP, a novel FMRP (fragile X mental retardation protein) interacting protein, shows a cell cycle-dependent intracellular localization". Hum Mol Genet. 12 (14): 1689–98. doi:10.1093/hmg/ddg181. PMID 12837692.
  6. Ramos A, Hollingworth D, Adinolfi S, Castets M, Kelly G, Frenkiel TA, Bardoni B, Pastore A (Jan 2006). "The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction". Structure. 14 (1): 21–31. doi:10.1016/j.str.2005.09.018. PMID 16407062.
  7. "Entrez Gene: NUFIP2 nuclear fragile X mental retardation protein interacting protein 2".
  8. Rehage N (2018). "Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA". Nature Communications. 9 (1): 299. Bibcode:2018NatCo...9..299R. doi:10.1038/s41467-017-02582-1. PMC 5775257. PMID 29352114.
Further reading

Further reading