NPTX2

NPTX2
Identifiers
Aliases	NPTX2, NARP, NP-II, NP2, neuronal pentraxin 2
External IDs	OMIM: 600750; MGI: 1858209; HomoloGene: 1892; GeneCards: NPTX2; OMA:NPTX2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	98,629,869 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	144,494,288 bp
RNA expression pattern
	Top expressed in
	beta cell; ; anterior pituitary; ; orbitofrontal cortex; ; Brodmann area 46; ; lateral nuclear group of thalamus; ; postcentral gyrus; ; prefrontal cortex; ; right testis; ; Brodmann area 10; ; Descending thoracic aorta;
	Top expressed in
	lumbar spinal ganglion; ; superior frontal gyrus; ; primary visual cortex; ; primary oocyte; ; secondary oocyte; ; prefrontal cortex; ; neural layer of retina; ; zygote; ; habenula; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; carbohydrate binding; molecular function;
Cellular component	extracellular region; cellular component; plasma membrane; cytoplasmic side of plasma membrane; filopodium; dendrite; growth cone; soma; glutamatergic synapse;
Biological process	associative learning; chemical synaptic transmission; neuron projection development; regulation of postsynaptic neurotransmitter receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4885
	53324
	ENSG00000106236
	ENSMUSG00000059991
	P47972
	O70340
	NM_002523
	NM_016789
	NP_002514
	NP_058069
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.⁵⁶

Function

This gene encodes a member of the family of neuronal pentraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.⁶

Clinical significance

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD

References

GRCh38: Ensembl release 89: ENSG00000106236 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000059991 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hsu YC, Perin MS (Feb 1996). "Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization". Genomics. 28 (2): 220–7. doi:10.1006/geno.1995.1134. PMID 8530029.
"Entrez Gene: NPTX2 neuronal pentraxin II".

Further reading

Park JK, Ryu JK, Lee KH, et al. (2007). "Quantitative analysis of NPTX2 hypermethylation is a promising molecular diagnostic marker for pancreatic cancer". Pancreas. 35 (3): e9–15. doi:10.1097/MPA.0b013e318153fa42. PMID 17895837. S2CID 31006962.
Marui T, Koishi S, Funatogawa I, et al. (2007). "No association between the neuronal pentraxin II gene polymorphism and autism". Prog. Neuropsychopharmacol. Biol. Psychiatry. 31 (4): 940–3. doi:10.1016/j.pnpbp.2007.02.016. PMID 17408830. S2CID 23877321.
Poulsen TT, Pedersen N, Perin MS, et al. (2006). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
Dodds DC, Omeis IA, Cushman SJ, et al. (1997). "Neuronal pentraxin receptor, a novel putative integral membrane pentraxin that interacts with neuronal pentraxin 1 and 2 and taipoxin-associated calcium-binding protein 49". J. Biol. Chem. 272 (34): 21488–94. doi:10.1074/jbc.272.34.21488. PMID 9261167.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106236 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059991 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530029-5] Hsu YC, Perin MS (Feb 1996). "Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization". Genomics. 28 (2): 220–7. doi:10.1006/geno.1995.1134. PMID 8530029.

[entrez-6] "Entrez Gene: NPTX2 neuronal pentraxin II".

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