NPRL2

NPRL2
Identifiers
Aliases	NPRL2, NPR2, NPR2L, TUSC4, NPR2-like, GATOR1 complex subunit, FFEVF2, NPR2 like, GATOR1 complex subunit
External IDs	OMIM: 607072; MGI: 1914482; HomoloGene: 4771; GeneCards: NPRL2; OMA:NPRL2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,350,826 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,422,905 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; right hemisphere of cerebellum; ; body of pancreas; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; pituitary gland; ; anterior pituitary; ; prefrontal cortex; ; right frontal lobe; ; apex of heart;
	Top expressed in
	interventricular septum; ; primary oocyte; ; right kidney; ; proximal tubule; ; spermatocyte; ; neural tube; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; secondary oocyte; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; protein binding; GTPase activator activity;
Cellular component	GATOR1 complex; lysosome; lysosomal membrane; membrane;
Biological process	negative regulation of TOR signaling; cellular response to amino acid starvation; negative regulation of kinase activity; positive regulation of GTPase activity; protein phosphorylation; cellular response to nitrogen starvation; positive regulation of autophagy; regulation of autophagosome assembly;
	Sources:Amigo / QuickGO
Orthologs
	10641
	56032
	ENSG00000114388
	ENSMUSG00000010057
	Q8WTW4
	Q9WUE4
	NM_006545
	NM_018879
	NP_006536
	NP_061367
	Wikidata
View/Edit Human	View/Edit Mouse

Nitrogen permease regulator 2-like protein (NPRL2) also known as tumor suppressor candidate 4 (TUSC4) is a protein that in humans is encoded by the NPRL2 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000114388 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000010057 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.
"Entrez Gene: TUSC4 tumor suppressor candidate 4".

Further reading

Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Ueda K, Kawashima H, Ohtani S, Deng WG, Ravoori M, Bankson J, Gao B, Girard L, Minna JD, Roth JA, Kundra V, Ji L (Oct 2006). "The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells". Cancer Research. 66 (19): 9682–90. doi:10.1158/0008-5472.CAN-06-1483. PMID 17018626.
Li J, Wang F, Haraldson K, Protopopov A, Duh FM, Geil L, Kuzmin I, Minna JD, Stanbridge E, Braga E, Kashuba VI, Klein G, Lerman MI, Zabarovsky ER (Sep 2004). "Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C". Cancer Research. 64 (18): 6438–43. doi:10.1158/0008-5472.CAN-03-3869. PMID 15374952.
Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD (May 2002). "Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo". Cancer Research. 62 (9): 2715–20. PMC 3478680. PMID 11980673.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114388 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000010057 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11085536-5] Lerman MI, Minna JD (Nov 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.

[entrez-6] "Entrez Gene: TUSC4 tumor suppressor candidate 4".

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