NLRP6

NLRP6
Identifiers
Aliases	NLRP6, AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NLR family, pyrin domain containing 6, NLR family pyrin domain containing 6
External IDs	OMIM: 609650; MGI: 2141990; GeneCards: NLRP6
Gene location (Human)
Chr.	Chromosome 11 (human)
End	285,388 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	140,509,105 bp
RNA expression pattern
	Top expressed in
	blood; ; granulocyte; ; right lobe of liver; ; spleen; ; appendix; ; duodenum; ; left uterine tube; ; right lung; ; monocyte; ; lymph node;
	Top expressed in
	Paneth cell; ; jejunum; ; crypt of lieberkuhn of small intestine; ; left lobe of liver; ; duodenum; ; colon; ; ileum; ; right kidney; ; intestinal villus; ; left colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; vasopressin receptor activity; ATP binding;
Cellular component	cytoplasm; nuclear membrane; membrane; plasma membrane; inflammasome complex; nucleus;
Biological process	response to bacterium; immune system process; wound healing; regulation of mucus secretion; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of immune response; regulation of autophagy; negative regulation of toll-like receptor signaling pathway; negative regulation of inflammatory response to antigenic stimulus; regulation of inflammatory response; negative regulation of MAPK cascade; negative regulation of ERK1 and ERK2 cascade; innate immune response; inflammatory response; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	171389
	101613
	ENSG00000174885
	ENSMUSG00000038745
	P59044
	Q91WS2
	NM_001276700; NM_138329
	NM_001081389; NM_133946
	NP_001263629; NP_612202
	NP_598707
	Wikidata
View/Edit Human	View/Edit Mouse

NLRP6, short for NOD-like receptor family pyrin domain containing 6, is an intracellular protein that plays a role in the immune system. It is also known as NALP6, PYPAF5, PAN3, and CLR11.4, and is one of 14 pyrin domain containing members of the NOD-like receptor family of pattern recognition receptors. As with several other NOD-like receptors, NLRP6's role in immunity is related to its ability to regulate caspase-1 and NF-κB activity.⁵

References

GRCh38: Ensembl release 89: ENSG00000174885 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038745 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. Bibcode:2002FEBSL.530...73G. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. S2CID 25023390.

Further reading

Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
Albrecht M, Domingues FS, Schreiber S, Lengauer T (2003). "Identification of mammalian orthologs associates PYPAF5 with distinct functional roles". FEBS Lett. 538 (1–3): 173–7. Bibcode:2003FEBSL.538..173A. doi:10.1016/S0014-5793(03)00161-3. PMID 12633874. S2CID 7730963.
Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
Wang L, Manji GA, Grenier JM, et al. (2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J. Biol. Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174885 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038745 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12387869-5] Grenier JM, Wang L, Manji GA, et al. (October 2002). "Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1". FEBS Lett. 530 (1–3): 73–8. Bibcode:2002FEBSL.530...73G. doi:10.1016/S0014-5793(02)03416-6. PMID 12387869. S2CID 25023390.

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