NLGN2

NLGN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3BL8
Identifiers
Aliases	NLGN2, neuroligin 2
External IDs	OMIM: 606479; MGI: 2681835; HomoloGene: 69317; GeneCards: NLGN2; OMA:NLGN2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,419,860 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,728,610 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; superior frontal gyrus; ; right ovary; ; primary visual cortex; ; ganglionic eminence; ; body of uterus; ; right frontal lobe; ; stromal cell of endometrium; ; left ovary; ; nucleus accumbens;
	Top expressed in
	subiculum; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; superior colliculus; ; anterior amygdaloid area; ; primary visual cortex; ; internal carotid artery; ; superior frontal gyrus; ; cerebellar cortex; ; cerebellar vermis;
	More reference expression data
	n/a
Gene ontology
Molecular function	carboxylic ester hydrolase activity; neurexin family protein binding; cell adhesion molecule binding; signaling receptor activity; identical protein binding;
Cellular component	integral component of membrane; postsynaptic membrane; membrane; synapse; inhibitory synapse; cell surface; cell junction; presynaptic membrane; plasma membrane; integral component of plasma membrane; integral component of postsynaptic membrane; intracellular anatomical structure; spanning component of membrane; glycinergic synapse; dopaminergic synapse; GABA-ergic synapse; symmetric, GABA-ergic, inhibitory synapse; integral component of postsynaptic specialization membrane;
Biological process	neuromuscular process controlling balance; neuron cell-cell adhesion; positive regulation of inhibitory postsynaptic potential; synapse organization; modulation of chemical synaptic transmission; positive regulation of protein localization to synapse; gephyrin clustering involved in postsynaptic density assembly; postsynaptic density protein 95 clustering; positive regulation of synaptic transmission, GABAergic; regulation of AMPA receptor activity; locomotory exploration behavior; regulation of respiratory gaseous exchange by nervous system process; cell-cell junction maintenance; positive regulation of synaptic vesicle clustering; positive regulation of synaptic transmission, glutamatergic; cell adhesion; positive regulation of excitatory postsynaptic potential; sensory perception of pain; terminal button organization; protein localization to synapse; positive regulation of insulin secretion; positive regulation of synapse assembly; inhibitory synapse assembly; synapse assembly; synaptic vesicle endocytosis; postsynaptic membrane assembly; presynaptic membrane assembly; cell-cell adhesion; postsynaptic specialization assembly; presynapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	57555
	216856
	ENSG00000169992; ENSG00000283859
	ENSMUSG00000051790
	Q8NFZ4
	Q69ZK9
	NM_020795
	NM_198862; NM_001364137
	NP_065846
	NP_942562; NP_001351066
	Wikidata
View/Edit Human	View/Edit Mouse

Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene.⁵⁶⁷

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.⁷

References

ENSG00000283859 GRCh38: Ensembl release 89: ENSG00000169992, ENSG00000283859 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000051790 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
"Entrez Gene: NLGN2 neuroligin 2".

Further reading

Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ..." Curr. Biol. 10 (17): R620–3. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085. S2CID 15851386.
Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID 9278515.
Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID 9647694. S2CID 36534759.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652. S2CID 16095623.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC 1925054. PMID 12669065.

[refGRCh38Ensembl-1] ENSG00000283859 GRCh38: Ensembl release 89: ENSG00000169992, ENSG00000283859 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051790 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10767552-5] Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.

[pmid10819331-6] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[entrez-7] "Entrez Gene: NLGN2 neuroligin 2".

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