Article · Wikipedia archive · Last revised Jun 11, 2026

Nitecapone

Nitecapone is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT). It was patented as an antiparkinson medication but was never marketed.

Last revised
Jun 11, 2026
Read time
≈ 1 min
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119 w
Citations
3
Source
Wikipedia ↗
Nitecapone
Skeletal formula
Space-filling model
Clinical data
ATC code
  • None
Identifiers
  • 3-[(3,4-Dihydroxy-5-nitrophenyl)methylidene]pentane-2,4-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H11NO6
Molar mass265.221 g·mol−1
3D model (JSmol)
  • [O-][N+](=O)c1cc(\C=C(/C(=O)C)C(=O)C)cc(O)c1O
  • InChI=1S/C12H11NO6/c1-6(14)9(7(2)15)3-8-4-10(13(18)19)12(17)11(16)5-8/h3-5,16-17H,1-2H3
  • Key:UPMRZALMHVUCIN-UHFFFAOYSA-N

Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).12 It was patented as an antiparkinson medication but was never marketed.1

See also

See also

References

References

  1. F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1635. ISBN 978-0-412-46630-4. Retrieved 20 May 2012.
  2. Nissinen E, Lindén IB, Schultz E, Kaakkola S, Männistö PT, Pohto P (August 1988). "Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat". European Journal of Pharmacology. 153 (2–3): 263–9. doi:10.1016/0014-2999(88)90614-0. PMID 3181288.