Neurogenin-2

NEUROG2
Identifiers
Aliases	NEUROG2, Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2
External IDs	OMIM: 606624; MGI: 109619; HomoloGene: 7633; GeneCards: NEUROG2; OMA:NEUROG2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	112,516,180 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	127,429,280 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; gonad; ; right hemisphere of cerebellum; ; putamen; ; amygdala; ; caudate nucleus; ; hippocampus proper; ; prefrontal cortex; ; anterior cingulate cortex;
	Top expressed in
	ventricular zone; ; rhombic lip; ; fossa; ; urethra; ; ganglion of neuraxis; ; ganglionic eminence; ; pretectal area; ; neural crest; ; condyle; ; zona limitans intrathalamica;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; E-box binding; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; nervous system development; regulation of transcription, DNA-templated; positive regulation of DNA-binding transcription factor activity; neuron differentiation; cell differentiation; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	63973
	11924
	ENSG00000178403
	ENSMUSG00000027967
	Q9H2A3
	P70447
	NM_024019
	NM_009718
	NP_076924
	NP_033848
	Wikidata
View/Edit Human	View/Edit Mouse

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.⁵

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.⁶

It has been found to reprogram astrocytes into glutamatergic neurons when expressed.⁷

References

GRCh38: Ensembl release 89: ENSG00000178403 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000027967 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: neurogenin 2".
Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, et al. (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature. 455 (7209): 114–118. Bibcode:2008Natur.455..114H. doi:10.1038/nature07198. PMID 18690213. S2CID 2813030.
Liu F, Zhang Y, Chen F, Yuan J, Li S, Han S, et al. (March 2021). "Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord". Cell Death & Disease. 12 (3): 225. doi:10.1038/s41419-021-03498-x. PMC 7921562. PMID 33649354.

Further reading

Gradwohl G, Fode C, Guillemot F (November 1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Developmental Biology. 180 (1): 227–241. doi:10.1006/dbio.1996.0297. PMID 8948587.
Simmons AD, Horton S, Abney AL, Johnson JE (January 2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Developmental Biology. 229 (2): 327–339. doi:10.1006/dbio.2000.9984. PMID 11203697.
Kumar M, Bagchi B, Gupta SK, Meena AS, Gressens P, Mani S (August 2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells and Development. 16 (4): 667–681. doi:10.1089/scd.2006.0115. PMID 17784840.
Deng S, Deng H, Le W, Xu H, Yang H, Deng X, et al. (January 2010). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neuroscience Letters. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID 19879328. S2CID 27698762.
Park CH, Kang JS, Yoon EH, Shim JW, Suh-Kim H, Lee SH (March 2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Letters. 582 (5): 537–542. Bibcode:2008FEBSL.582..537P. doi:10.1016/j.febslet.2008.01.018. PMID 18242186. S2CID 33390799.
Fode C, Gradwohl G, Morin X, Dierich A, LeMeur M, Goridis C, et al. (March 1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–494. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123. S2CID 16790307.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178403 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027967 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: neurogenin 2".

[pmid18690213-6] Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, et al. (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature. 455 (7209): 114–118. Bibcode:2008Natur.455..114H. doi:10.1038/nature07198. PMID 18690213. S2CID 2813030.

[7] Liu F, Zhang Y, Chen F, Yuan J, Li S, Han S, et al. (March 2021). "Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord". Cell Death & Disease. 12 (3): 225. doi:10.1038/s41419-021-03498-x. PMC 7921562. PMID 33649354.

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