Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage.1 Increased nesfatin-1 in the hypothalamus contributes to diminished hunger, a 'sense of fullness', and a potential loss of body fat and weight.
A study of metabolic effects of nesfatin-1 in rats was done in which subjects administered nesfatin-1 ate less, used more stored fat and became more active. Nesfatin-1-induced inhibition of feeding may be mediated through the inhibition of orexigenic neurons.2 In addition, the protein stimulated insulin secretion from the pancreatic beta cells of both rats and mice.3 Nesfatin-1 can cross the blood–brain barrier without saturation.4
References
References
- Oh-i, Shinsuke; Shimizu, Hiroyuki; Satoh, Tetsurou; Okada, Shuichi; Adachi, Sachika; Inoue, Kinji; Eguchi, Hiroshi; Yamamoto, Masanori; et al. (2006). "Identification of nesfatin-1 as a satiety molecule in the hypothalamus". Nature. 443 (7112): 709–12. Bibcode:2006Natur.443..709O. doi:10.1038/nature05162. PMID 17036007. S2CID 4366701.
- Price, Christopher J.; Samson, Willis K.; Ferguson, Alastair V. (2008). "Nesfatin-1 inhibits NPY neurons in the arcuate nucleus". Brain Research. 1230: 99–106. doi:10.1016/j.brainres.2008.06.084. PMC 2590930. PMID 18625211.
- Gonzalez, R.; Reingold, B. K.; Gao, X.; Gaidhu, M. P.; Tsushima, R.; Unniappan, S. (2011). "Nesfatin-1 Exerts a Direct, Glucose-Dependent Insulinotropic Action on Mouse Islet Beta and MIN6 Cells". Journal of Endocrinology. 208 (3): R9–R16. doi:10.1530/JOE-10-0492. PMID 21224288.
- Pan, Weihong; Hsuchou, Hung; Kastin, Abba J. (2007). "Nesfatin-1 crosses the blood–brain barrier without saturation". Peptides. 28 (11): 2223–8. doi:10.1016/j.peptides.2007.09.005. PMID 17950952. S2CID 17973594.
- ProSci inc. "Nesfatin-1 Recombinant Protein". Retrieved 21 March 2013.
{{cite web}}: CS1 maint: deprecated archival service (link) - Stengel, A.; Tache, Y. (2011). "Minireview: Nesfatin-1--An Emerging New Player in the Brain-Gut, Endocrine, and Metabolic Axis". Endocrinology. 152 (11): 4033–8. doi:10.1210/en.2011-1500. PMC 3199002. PMID 21862618.
- Maejima, Yuko; Sedbazar, Udval; Suyama, Shigetomo; Kohno, Daisuke; Onaka, Tatsushi; Takano, Eisuke; Yoshida, Natsu; Koike, Masato; et al. (2009). "Nesfatin-1-Regulated Oxytocinergic Signaling in the Paraventricular Nucleus Causes Anorexia through a Leptin-Independent Melanocortin Pathway". Cell Metabolism. 10 (5): 355–65. doi:10.1016/j.cmet.2009.09.002. PMID 19883614.
- Shimizu, H; Ohsaki, A; Oh-I, S; Okada, S; Mori, M (May 2009). "A new anorexigenic protein, nesfatin-1". Peptides. 30 (5): 995–8. doi:10.1016/j.peptides.2009.01.002. PMID 19452636. S2CID 3837217.
- Shimizu, H.; Oh-i, S.; Hashimoto, K.; Nakata, M.; Yamamoto, S.; Yoshida, N.; Eguchi, H.; Kato, I.; et al. (2008). "Peripheral Administration of Nesfatin-1 Reduces Food Intake in Mice: The Leptin-Independent Mechanism". Endocrinology. 150 (2): 662–71. doi:10.1210/en.2008-0598. PMID 19176321.
- Zhang, Z.; Li, L.; Yang, M.; Liu, H.; Boden, G.; Yang, G. (2011). "Increased Plasma Levels of Nesfatin-1 in Patients with Newly Diagnosed Type 2 Diabetes Mellitus". Experimental and Clinical Endocrinology & Diabetes. 120 (2): 91–95. doi:10.1055/s-0031-1286339. PMID 22020667.
- Yang, M.; Zhang, Z.; Wang, C.; Li, K.; Li, S.; Boden, G.; Li, L.; Yang, G. (2012). "Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance". Diabetes. 61 (8): 1959–68. doi:10.2337/db11-1755. PMC 3402309. PMID 22688332.
- Stengel, A.; Goebel, M.; Wang, L.; Rivier, J.; Kobelt, P.; Monnikes, H.; Lambrecht, N. W. G.; Tache, Y. (2009). "Central Nesfatin-1 Reduces Dark-Phase Food Intake and Gastric Emptying in Rats: Differential Role of Corticotropin-Releasing Factor2 Receptor". Endocrinology. 150 (11): 4911–9. doi:10.1210/en.2009-0578. PMC 2775975. PMID 19797401.
External links
External links
- nesfatin-1+protein,+rat at the U.S. National Library of Medicine Medical Subject Headings (MeSH)