NEDD1

NEDD1
Identifiers
Aliases	NEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1, NEDD1 gamma-tubulin ring complex targeting factor
External IDs	OMIM: 600372; MGI: 97293; HomoloGene: 7439; GeneCards: NEDD1; OMA:NEDD1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	96,953,780 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	92,558,282 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; sperm; ; vastus lateralis muscle; ; deltoid muscle; ; buccal mucosa cell; ; ventricular zone; ; Skeletal muscle tissue of biceps brachii; ; tibialis anterior muscle;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; atrium; ; right ventricle; ; cardiac muscles; ; digastric muscle; ; genital tubercle; ; myocardium of ventricle; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule organizing center; ciliary basal body; centriole; cytosol; centrosome; apical part of cell; spindle pole; pericentriolar material; cytoskeleton;
Biological process	cell division; protein localization to centrosome; cell cycle; G2/M transition of mitotic cell cycle; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	121441
	17997
	ENSG00000139350
	ENSMUSG00000019988
	Q8NHV4
	P33215
	NM_001135175; NM_001135176; NM_001135177; NM_152905
	NM_008682
	NP_001128647; NP_001128648; NP_001128649; NP_690869
	NP_032708
	Wikidata
View/Edit Human	View/Edit Mouse

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene⁵ and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

References

GRCh38: Ensembl release 89: ENSG00000139350 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000019988 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

Further reading

Pinyol R, Scrofani J, Vernos I (2012). "The role of NEDD1 phosphorylation by Aurora A in chromosomal microtubule nucleation and spindle function". Curr. Biol. 23 (2): 143–9. doi:10.1016/j.cub.2012.11.046. hdl:10230/23504. PMID 23273898.
Sdelci S, Schütz M, Pinyol R, et al. (2012). "Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome". Curr. Biol. 22 (16): 1516–23. Bibcode:2012CBio...22.1516S. doi:10.1016/j.cub.2012.06.027. PMID 22818914.
Haren L, Remy MH, Bazin I, et al. (2006). "NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly". J. Cell Biol. 172 (4): 505–15. doi:10.1083/jcb.200510028. PMC 2063671. PMID 16461362.
Lüders J, Patel UK, Stearns T (2006). "GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation". Nat. Cell Biol. 8 (2): 137–47. doi:10.1038/ncb1349. PMID 16378099. S2CID 27587898.
Jung SY, Malovannaya A, Wei J, et al. (2005). "Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes". Mol. Endocrinol. 19 (10): 2451–65. doi:10.1210/me.2004-0476. PMID 16051665. S2CID 24948585.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takai S, Yoshida Y, Noda M, et al. (1995). "Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization". Hum. Genet. 95 (1): 96–8. doi:10.1007/BF00225082. PMID 7814034. S2CID 902030.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139350 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019988 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

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