NECAP2

NECAP2
Identifiers
Aliases	NECAP2, NECAP endocytosis associated 2
External IDs	OMIM: 611624; MGI: 1913397; HomoloGene: 9168; GeneCards: NECAP2; OMA:NECAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	16,460,078 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,805,668 bp
RNA expression pattern
	Top expressed in
	oocyte; ; granulocyte; ; monocyte; ; spleen; ; lymph node; ; secondary oocyte; ; appendix; ; stromal cell of endometrium; ; right lung; ; upper lobe of left lung;
	Top expressed in
	stroma of bone marrow; ; granulocyte; ; lip; ; right kidney; ; gastrula; ; blood; ; lens; ; yolk sac; ; spermatocyte; ; stomach;
	More reference expression data
	More reference expression data
Orthologs
	55707
	66147
	ENSG00000157191
	ENSMUSG00000028923
	Q9NVZ3
	Q9D1J1
	NM_001145277; NM_001145278; NM_018090
	NM_025383
	NP_001138749; NP_001138750; NP_060560
	NP_079659
	Wikidata
View/Edit Human	View/Edit Mouse

Adaptin ear-binding coat-associated protein 2 is a protein that in humans is encoded by the NECAP2 gene.⁵⁶⁷

Interactions

NECAP2 has been shown to interact with AP1G1.⁸

References

GRCh38: Ensembl release 89: ENSG00000157191 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028923 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ritter B, Philie J, Girard M, Tung EC, Blondeau F, McPherson PS (Oct 2003). "Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif". EMBO Rep. 4 (11): 1089–95. doi:10.1038/sj.embor.embor7400004. PMC 1326374. PMID 14555962.
Ritter B, Blondeau F, Denisov AY, Gehring K, McPherson PS (Oct 2004). "Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics". Biochem. Soc. Trans. 32 (Pt 5): 769–73. doi:10.1042/BST0320769. PMID 15494011.
"Entrez Gene: NECAP2 NECAP endocytosis associated 2".
Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (2000). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157191 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028923 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14555962-5] Ritter B, Philie J, Girard M, Tung EC, Blondeau F, McPherson PS (Oct 2003). "Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif". EMBO Rep. 4 (11): 1089–95. doi:10.1038/sj.embor.embor7400004. PMC 1326374. PMID 14555962.

[pmid15494011-6] Ritter B, Blondeau F, Denisov AY, Gehring K, McPherson PS (Oct 2004). "Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics". Biochem. Soc. Trans. 32 (Pt 5): 769–73. doi:10.1042/BST0320769. PMID 15494011.

[entrez-7] "Entrez Gene: NECAP2 NECAP endocytosis associated 2".

[pmid14665628-8] Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J. Biol. Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.

1

2

3

4

5

6

7

8