NDC1

NDC1
Identifiers
Aliases	NDC1, NET3, TMEM48, NDC1 transmembrane nucleoporin
External IDs	OMIM: 610115; MGI: 1920037; HomoloGene: 41224; GeneCards: NDC1; OMA:NDC1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	53,838,463 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	107,273,543 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; ventricular zone; ; tibia; ; gingival epithelium; ; epithelium of nasopharynx; ; mucosa of colon; ; mucosa of sigmoid colon; ; germinal epithelium; ; testicle;
	Top expressed in
	tail of embryo; ; genital tubercle; ; primitive streak; ; cumulus cell; ; spermatocyte; ; epiblast; ; maxillary prominence; ; condyle; ; yolk sac; ; medullary collecting duct;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of nuclear pore;
Cellular component	cytoplasm; integral component of membrane; nuclear membrane; nuclear envelope; membrane; plasma membrane; nuclear pore; actin cytoskeleton; nucleus; spindle pole body; nuclear pore transmembrane ring; host cell;
Biological process	mRNA transport; nuclear pore complex assembly; viral transcription; protein sumoylation; mitotic nuclear membrane disassembly; homologous chromosome pairing at meiosis; spermatogenesis; protein transport; regulation of cellular response to heat; viral process; mRNA export from nucleus; intracellular transport of virus; tRNA export from nucleus; spindle pole body duplication; regulation of gene silencing by miRNA; regulation of glycolytic process; transport; nuclear pore organization;
	Sources:Amigo / QuickGO
Orthologs
	55706
	72787
	ENSG00000058804
	ENSMUSG00000028614
	Q9BTX1
	Q8VCB1
	NM_001168551; NM_018087
	NM_028355
	NP_001162023; NP_060557
	NP_082631
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene.⁵⁶⁷ It anchors aladin to the nuclear pore complex.⁸

References

GRCh38: Ensembl release 89: ENSG00000058804 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028614 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lau CK, Delmar VA, Forbes DJ (Aug 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". Anat Rec A. 288 (7): 681–94. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.
Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.
"Entrez Gene: TMEM48 transmembrane protein 48".
Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Mol. Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
Stavru F, Hülsmann BB, Spang A, et al. (2006). "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes" (PDF). J. Cell Biol. 173 (4): 509–19. doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000058804 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028614 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16779818-5] Lau CK, Delmar VA, Forbes DJ (Aug 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". Anat Rec A. 288 (7): 681–94. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.

[pmid12958361-6] Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.

[entrez-7] "Entrez Gene: TMEM48 transmembrane protein 48".

[8] Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.

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