Narcotoline

Narcotoline
	source ↗
Names
	Preferred IUPAC name (3S)-3-[(5R)-4-Hydroxy-6-methyl-5,6,7,8-tetrahydro-2H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6,7-dimethoxy-2-benzofuran-1(3H)-one
Identifiers
CAS Number	521-40-4 Y;
3D model (JSmol)	Interactive image;
ChemSpider	390785 N;
ECHA InfoCard	100.007.559
EC Number	208-313-6;
KEGG	C09593 N;
PubChem CID	442330;
UNII	M5V1K1QE3F Y;
CompTox Dashboard (EPA)	DTXSID50200098 ;
	InChI InChI=1S/C21H21NO7/c1-22-7-6-10-8-13-20(28-9-27-13)17(23)14(10)16(22)18-11-4-5-12(25-2)19(26-3)15(11)21(24)29-18/h4-5,8,16,18,23H,6-7,9H2,1-3H3/t16-,18+/m1/s1 N Key: LMGZCSKYOKDBES-AEFFLSMTSA-N N; InChI=1/C21H21NO7/c1-22-7-6-10-8-13-20(28-9-27-13)17(23)14(10)16(22)18-11-4-5-12(25-2)19(26-3)15(11)21(24)29-18/h4-5,8,16,18,23H,6-7,9H2,1-3H3/t16-,18+/m1/s1 Key: LMGZCSKYOKDBES-AEFFLSMTBE;
	SMILES CN1CCC2=CC3=C(C(=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)O)OCO3;
Properties
Chemical formula	C21H21NO7
Molar mass	399.399 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Narcotoline is an opiate alkaloid chemically related to noscapine. It binds to the same receptors in the brain as noscapine to act as an antitussive,¹ and has also been used in tissue culture media.²

Sources

It can be obtained from the opium poppy, Papaver somniferum. It is present at much higher levels in culinary strains (cultivars) of P. somniferum used for poppy seed production than in high-morphine pharmaceutical strains used for opium production.³

References

Karlsson, MO; Dahlström, B; Neil, A (1988). "Characterization of high-affinity binding sites for the antitussive 3Hnoscapine in guinea pig brain tissue". European Journal of Pharmacology. 145 (2): 195–203. doi:10.1016/0014-2999(88)90230-0. PMID 3350041.
US 2004063205 "Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro"
Frick, S; Kramell, R; Schmidt, J; Fist, AJ; Kutchan, TM (2005). "Comparative qualitative and quantitative determination of alkaloids in narcotic and condiment Papaver somniferum cultivars". Journal of Natural Products. 68 (5): 666–73. doi:10.1021/np0496643. PMID 15921406.

External links

KEGG compound C09593

[1] Karlsson, MO; Dahlström, B; Neil, A (1988). "Characterization of high-affinity binding sites for the antitussive 3Hnoscapine in guinea pig brain tissue". European Journal of Pharmacology. 145 (2): 195–203. doi:10.1016/0014-2999(88)90230-0. PMID 3350041.

[2] US 2004063205 "Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro"

[3] Frick, S; Kramell, R; Schmidt, J; Fist, AJ; Kutchan, TM (2005). "Comparative qualitative and quantitative determination of alkaloids in narcotic and condiment Papaver somniferum cultivars". Journal of Natural Products. 68 (5): 666–73. doi:10.1021/np0496643. PMID 15921406.

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