Myosin-2

MYH2
Identifiers
Aliases	MYH2, IBM3, MYH2A, MYHSA2, MYHas8, MyHC-2A, MyHC-IIa, MYPOP, myosin, heavy chain 2, skeletal muscle, adult, myosin heavy chain 2
External IDs	OMIM: 160740; MGI: 1339710; HomoloGene: 23019; GeneCards: MYH2; OMA:MYH2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	10,549,700 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	67,088,343 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; body of tongue; ; vastus lateralis muscle; ; thoracic diaphragm; ; triceps brachii muscle; ; glutes; ; muscle of thigh; ; deltoid muscle; ; gastrocnemius muscle;
	Top expressed in
	soleus muscle; ; intercostal muscle; ; sternocleidomastoid muscle; ; ankle; ; masseter muscle; ; temporal muscle; ; extraocular muscle; ; digastric muscle; ; medial head of gastrocnemius muscle; ; vastus lateralis muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; actin binding; microfilament motor activity; protein binding; cytoskeletal motor activity; ATP binding; calmodulin binding; actin filament binding; microtubule motor activity; microtubule binding;
Cellular component	cytoplasm; myosin filament; cytosol; myofibril; sarcomere; myosin complex; A band; protein-containing complex; Golgi apparatus; actomyosin contractile ring; muscle myosin complex; cell-cell junction;
Biological process	Fc-gamma receptor signaling pathway involved in phagocytosis; muscle filament sliding; microtubule-based movement; plasma membrane repair; muscle contraction; response to activity; actin-mediated cell contraction;
	Sources:Amigo / QuickGO
Orthologs
	4620
	17882
	ENSG00000125414
	ENSMUSG00000033196
	Q9UKX2
	G3UW82
	NM_017534; NM_001100112
	NM_001039545; NM_144961
	NP_001093582; NP_060004
	NP_001034634
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-2 (myosin heavy chain 2) is a protein that in humans is encoded by the MYH2 gene.⁵⁶

References

GRCh38: Ensembl release 89: ENSG00000125414 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000033196 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. doi:10.1152/ajpcell.1994.267.6.C1723. PMID 7545970.
"Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

Further reading

Schwartz CE, McNally E, Leinwand L, Skolnick MH (1987). "A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13". Cytogenet. Cell Genet. 43 (1–2): 117–20. doi:10.1159/000132307. PMID 2877813.
Ennion S, Sant'ana Pereira J, Sargeant AJ, et al. (1995). "Characterization of human skeletal muscle fibres according to the myosin heavy chains they express". J. Muscle Res. Cell. Motil. 16 (1): 35–43. doi:10.1007/BF00125308. PMID 7751403. S2CID 22270940.
Hisatome I, Morisaki T, Kamma H, et al. (1998). "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870–81. doi:10.1152/ajpcell.1998.275.3.C870. PMID 9730972.
Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. Bibcode:1999PNAS...96.2958W. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Onuoha GN, Alpar EK, Laprade M, et al. (1999). "Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle". Clinical and Investigative Medicine. 22 (5): 180–4. PMID 10579056.
Martinsson T, Oldfors A, Darin N, et al. (2001). "Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14614–9. doi:10.1073/pnas.250289597. PMC 18967. PMID 11114175.
Tajsharghi H, Thornell LE, Darin N, et al. (2002). "Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age". Neurology. 58 (5): 780–6. doi:10.1212/wnl.58.5.780. PMID 11889243. S2CID 31098150.
England K, Ashford D, Kidd D, Rumsby M (2002). "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. 14 (6): 529–36. doi:10.1016/S0898-6568(01)00277-7. PMID 11897493.
Allen DL, Leinwand LA (2003). "Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter". J. Biol. Chem. 277 (47): 45323–30. doi:10.1074/jbc.M208302200. PMID 12235157.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kim EJ, Helfman DM (2003). "Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin". J. Biol. Chem. 278 (32): 30063–73. doi:10.1074/jbc.M304909200. PMID 12756252.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chung MC, Kawamoto S (2005). "IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation". J. Biol. Chem. 279 (53): 56042–52. doi:10.1074/jbc.M404791200. PMID 15496418.
Tajsharghi H, Darin N, Rekabdar E, et al. (2005). "Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2)". Eur. J. Hum. Genet. 13 (5): 617–22. doi:10.1038/sj.ejhg.5201375. PMID 15741996.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Li M, Lionikas A, Yu F, et al. (2006). "Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys)". Neuromuscul. Disord. 16 (11): 782–91. doi:10.1016/j.nmd.2006.07.023. PMC 1693964. PMID 17005402.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125414 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033196 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7545970-5] Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. doi:10.1152/ajpcell.1994.267.6.C1723. PMID 7545970.

[entrez-6] "Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

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