MYH4

MYH4
Identifiers
Aliases	MYH4, MYH2B, MyHC-2B, MyHC-IIb, myosin, heavy chain 4, skeletal muscle, myosin heavy chain 4
External IDs	OMIM: 160742; MGI: 1339713; HomoloGene: 123880; GeneCards: MYH4; OMA:MYH4 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	10,469,559 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	67,151,272 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; muscle of thigh; ; testicle; ; thoracic diaphragm; ; tibialis anterior muscle; ; gastrocnemius muscle;
	Top expressed in
	extensor digitorum longus muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; medial head of gastrocnemius muscle; ; sternocleidomastoid muscle; ; plantaris muscle; ; triceps brachii muscle; ; digastric muscle; ; temporal muscle; ; body of femur;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; actin binding; microfilament motor activity; double-stranded RNA binding; ATPase activity; cytoskeletal motor activity; ATP binding; calmodulin binding; actin filament binding; microtubule motor activity; microtubule binding;
Cellular component	cytoplasm; myosin filament; muscle myosin complex; myofibril; sarcomere; myosin complex;
Biological process	ATP metabolic process; muscle contraction; actin filament-based movement; muscle filament sliding; microtubule-based movement; response to activity;
	Sources:Amigo / QuickGO
Orthologs
	4622
	17884
	ENSG00000264424
	ENSMUSG00000057003
	Q9Y623
	Q5SX39
	NM_017533
	NM_010855
	NP_060003
	NP_034985
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.⁵

Function

MYH4 is a gene that encodes a sarcomeric myosin.

References

GRCh38: Ensembl release 89: ENSG00000264424 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000057003 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Edwards YH, Parkar M, Povey S, West LF, Parrington JM, Solomon E (May 1985). "Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe". Ann. Hum. Genet. 49 (Pt 2): 101–9. doi:10.1111/j.1469-1809.1985.tb01681.x. PMID 3000272. S2CID 7405468.

Further reading

Sant'ana Pereira JA, Wessels A, Nijtmans L, et al. (1995). "New method for the accurate characterization of single human skeletal muscle fibres demonstrates a relation between mATPase and MyHC expression in pure and hybrid fibre types". J. Muscle Res. Cell. Motil. 16 (1): 21–34. doi:10.1007/BF00125307. PMID 7751402. S2CID 20954615.
Weiss A, McDonough D, Wertman B, et al. (1999). "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. Bibcode:1999PNAS...96.2958W. doi:10.1073/pnas.96.6.2958. PMC 15877. PMID 10077619.
Barton PJ, Buckingham ME (1985). "The myosin alkali light chain proteins and their genes". Biochem. J. 231 (2): 249–61. doi:10.1042/bj2310249. PMC 1152739. PMID 3904738.
Horton MJ, Brandon CA, Morris TJ, et al. (2001). "Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres". Arch. Oral Biol. 46 (11): 1039–50. doi:10.1016/S0003-9969(01)00066-8. PMC 3848045. PMID 11543711.
Weiss A, Schiaffino S, Leinwand LA (1999). "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. doi:10.1006/jmbi.1999.2865. PMID 10388558.
Larsson L, Moss RL (1993). "Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles". J. Physiol. 472: 595–614. doi:10.1113/jphysiol.1993.sp019964. PMC 1160504. PMID 8145163.
Li ZH, Spektor A, Varlamova O, Bresnick AR (2003). "Mts1 regulates the assembly of nonmuscle myosin-IIA". Biochemistry. 42 (48): 14258–66. doi:10.1021/bi0354379. PMID 14640694.
Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
Ford HL, Silver DL, Kachar B, et al. (1997). "Effect of Mts1 on the structure and activity of nonmuscle myosin II". Biochemistry. 36 (51): 16321–7. doi:10.1021/bi971182l. PMID 9405067.
Soussi-Yanicostas N, Whalen RG, Petit C (1993). "Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome". Hum. Mol. Genet. 2 (5): 563–9. doi:10.1093/hmg/2.5.563. PMID 8518795.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000264424 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057003 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3000272-5] Edwards YH, Parkar M, Povey S, West LF, Parrington JM, Solomon E (May 1985). "Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe". Ann. Hum. Genet. 49 (Pt 2): 101–9. doi:10.1111/j.1469-1809.1985.tb01681.x. PMID 3000272. S2CID 7405468.

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