Mucin 17

MUC17
Identifiers
Aliases	MUC17, MUC3, MUC-17, MUC-3, mucin 17, cell surface associated
External IDs	OMIM: 608424; HomoloGene: 134646; GeneCards: MUC17; OMA:MUC17 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	101,058,859 bp
RNA expression pattern
	Top expressed in
	duodenum; ; rectum; ; testicle; ; transverse colon; ; right lobe of liver; ; smooth muscle tissue; ; appendix; ; sural nerve; ; islet of Langerhans; ; right lung;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	PDZ domain binding; extracellular matrix constituent, lubricant activity; protein binding;
Cellular component	Golgi lumen; integral component of membrane; extracellular region; membrane; external side of plasma membrane; apical plasma membrane; plasma membrane; collagen-containing extracellular matrix;
Biological process	cellular homeostasis; O-glycan processing; stimulatory C-type lectin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	140453
	n/a
	ENSG00000169876
	n/a
	Q685J3
	n/a
	NM_001004430; NM_001040105
	n/a
	NP_001035194
	n/a
	Wikidata
View/Edit Human

Mucin-17 is a protein that in humans is encoded by the MUC17 gene.³⁴

Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM]⁴

References

GRCh38: Ensembl release 89: ENSG00000169876 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Gum JR Jr; Crawley SC; Hicks JW; Szymkowski DE; Kim YS (Feb 2002). "MUC17, a novel membrane-tethered mucin". Biochem Biophys Res Commun. 291 (3): 466–475. doi:10.1006/bbrc.2002.6475. PMID 11855812.
"Entrez Gene: MUC17 mucin 17, cell surface associated".

Further reading

Kitamoto S, Yamada N, Yokoyama S, et al. (2011). "DNA methylation and histone H3-K9 modifications contribute to MUC17 expression". Glycobiology. 21 (2): 247–56. doi:10.1093/glycob/cwq155. PMC 3010767. PMID 20926598.
Malmberg EK, Pelaseyed T, Petersson AC, et al. (2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine" (PDF). Biochem. J. 410 (2): 283–9. doi:10.1042/BJ20071068. PMID 17990980. S2CID 207870.
Moniaux N, Junker WM, Singh AP, et al. (2006). "Characterization of human mucin MUC17. Complete coding sequence and organization". J. Biol. Chem. 281 (33): 23676–23685. doi:10.1074/jbc.M600302200. PMID 16737958.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–954. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Ho JJ, Jaituni RS, Crawley SC, et al. (2004). "N-glycosylation is required for the surface localization of MUC17 mucin". Int. J. Oncol. 23 (3): 585–92. doi:10.3892/ijo.23.3.585. PMID 12888891.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang R, Khatri IA, Forstner JF (2002). "C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components". Biochem. J. 366 (Pt 2): 623–31. doi:10.1042/BJ20020289. PMC 1222797. PMID 12027806.
Van Klinken BJ, Van Dijken TC, Oussoren E, et al. (1997). "Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region". Biochem. Biophys. Res. Commun. 238 (1): 143–148. doi:10.1006/bbrc.1997.7258. PMID 9299468.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169876 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11855812-3] Gum JR Jr; Crawley SC; Hicks JW; Szymkowski DE; Kim YS (Feb 2002). "MUC17, a novel membrane-tethered mucin". Biochem Biophys Res Commun. 291 (3): 466–475. doi:10.1006/bbrc.2002.6475. PMID 11855812.

[entrez-4] "Entrez Gene: MUC17 mucin 17, cell surface associated".

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